Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis.

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dc.contributor.authorOmotoso, Gabriel Olaiya
dc.contributor.authorGbadamosi, IT
dc.contributor.authorAfolabi, TT
dc.contributor.authorAbdulwahab, AB
dc.contributor.authorAkinlolu, AA
dc.date.accessioned2018-07-06T08:47:37Z
dc.date.available2018-07-06T08:47:37Z
dc.date.issued2018
dc.description.abstractCuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple sclerosis in which oxidative stress has been documented as one of the cascade in the pathogenesis. Moringa oleifera is a phytomedicinal plant with antioxidant and neuroprotective properties. This study aimed at evaluating the ameliorative capability of M. oleifera in cuprizone-induced behavioral and histopathological alterations in the prefrontal cortex and hippocampus of Wistar rats. Four groups of rats were treated with normal saline, cuprizone, M. oleifera and a combination of M. oleifera and cuprizone, for five weeks. The rats were subjected to Morris water maze and Y-maze to assess long and short-term memory respectively. The animals were sacrificed, and brain tissues were removed for histochemical and enzyme lysate immunosorbent assay for catalase, superoxide dismutase, and nitric oxide. Cuprizone significantly induced oxidative and nitrosative stress coupled with memory decline and cortico-hippocampal neuronal deficits; however, administration of M. oleifera significantly reversed the neuropathological deficits induced by cuprizone.en_US
dc.identifier.citation51:119-127.en_US
dc.identifier.otherhttps://acbjournal.org/DOIx.php?id=10.5115/acb.2018.51.2.119
dc.identifier.urihttp://hdl.handle.net/123456789/914
dc.language.isoenen_US
dc.publisherAnatomy and Cell Biology,en_US
dc.subjectcuprizone,en_US
dc.subjectMoringa oleifera,en_US
dc.subjectOxidative stressen_US
dc.subjectmemoryen_US
dc.titleAmeliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis.en_US
dc.typeArticleen_US

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