Moringa oleifera impairs the morphology and functions of the kidney in adult Wistar rats.

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dc.contributor.authorAkinlolu, AA
dc.contributor.authorGhazal, OK
dc.contributor.authorAmeen, OM
dc.contributor.authorOyebanji, SC
dc.contributor.authorOmotoso, Gabriel Olaiya
dc.date.accessioned2018-07-06T08:38:46Z
dc.date.available2018-07-06T08:38:46Z
dc.date.issued2014
dc.description.abstractSUMMARY: We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II ­ IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I ­ IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II ­ IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I ­ IV. Histological examinations showed normal cyto-architecture of the kidneys of rats of Group I while the Capsular spaces of the kidneys of rats of Groups II ­ IV appeared wider than those of Group I. Statistical analyses showed significant higher levels (P0.05) of Alanine and Aspartate Transaminases, and serum urea in rats of Groups II ­ IV in a non- dose-dependent manner when compared to rats of Group I. Our findings are consistent with the stated hypothesis.en_US
dc.identifier.citation32(2):469-474.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/904
dc.language.isoenen_US
dc.publisherInternational Journal of Morphology,en_US
dc.subjectMORINGAen_US
dc.subjectToxicity profileen_US
dc.subjectKidneyen_US
dc.titleMoringa oleifera impairs the morphology and functions of the kidney in adult Wistar rats.en_US
dc.typeArticleen_US

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