Oestrogenic effects of onion and garlic extracts: Potential alternatives to synthetic oestradiol

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dc.contributor.authorKadir R.E.
dc.contributor.authorIbrahim A.
dc.contributor.authorOderinde G.
dc.contributor.authorGwadabe M.S.
dc.contributor.authorOjulari L.S.
dc.contributor.authorBiliaminu S.A.
dc.date.accessioned2025-05-02T11:37:35Z
dc.date.available2025-05-02T11:37:35Z
dc.date.issued2018
dc.description.abstractThe aims of the study were to investigate the oestrogenic activities of onion and garlic and their effects on the uterus of adult female Wister rats. A total number of thirty (30) rats comprising of five (5) rats in six (6) groups were used. Group I received feeds and water only and served as the control. Group II (oestradiol group) was administered 10μg/kg of oestradiol orally. Groups III and IV were given 1.14gm/kg and 1.7gm/kg body weight of onion extract respectively while groups V and VI were given 1.14gm/kg and 1.7gm/kg body weight of garlic extract respectively for four weeks. The microscopic architectures of uterus of all the study animals were observed under light microscope following the preparation of the tissues (uterus) and subsequent staining with Hematoxylin and Eosin dyes; and serum oestrogen levels were also assayed and compared after four weeks of treatment. Animals in the control group have higher oestrogen levels than other treatment groups including oestradiol group. It was observed that the endometrium of animals in the low onion and oestradiol groups were thicker than the control and other treatment groups. Our study showed that low onion offered some protection to uterus in similar way synthetic oestradiol does. The use of onion or garlic as a potential alternative to synthetic oestradiol in the treatments of oestrogen depletion associated with menopause could not be established.
dc.identifier.citationKadir R.E., Ibrahim A., Oderinde G., Gwadabe M.S., Ojulari L.S. & Biliaminu S.A. (2018): Oestrogenic effects of onion and garlic extracts: Potential alternatives to synthetic oestradiol. The Tropical Journal of Health Sciences. 25(2):16-20. Published by College of Health Sciences, University of Ilorin. Available online at https://www.ajol.info/index.php/tjhc/issue/view/16945
dc.identifier.issn1117-4153
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15899
dc.language.isoen
dc.publisherCollege of Health Sciences, University of Ilorin
dc.relation.ispartofseriesVol 25, Issue 2; 16-20
dc.subjectonion
dc.subjectgarlic
dc.subjectoestrogen
dc.subjectWistar rat
dc.titleOestrogenic effects of onion and garlic extracts: Potential alternatives to synthetic oestradiol
dc.typeArticle

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