Evaluation of Anti-nociceptive and Anti-Inflammatory Activities of Leaf Extract of Turraea vogelii Hook. f. ex. Benth.

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dc.contributor.authorAyanniyi, Rashidat Oluwafunke
dc.contributor.authorOjuade, Fatimoh
dc.contributor.authorAbdul-Olumoh, Hidayah
dc.contributor.authorSalawu, Kayode
dc.contributor.authorOlufadi-Ahmed, Haishat
dc.contributor.authorAdebesi-Jose, Gbemisola
dc.date.accessioned2019-10-22T09:21:32Z
dc.date.available2019-10-22T09:21:32Z
dc.date.issued2019
dc.description.abstractThe leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The antiinflammatory activity was investigated using in vitro bovine serum albumin (BSA) denaturation assay and BSA induced hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005) inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (10mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T. vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional medicine for the management o f pain and inflammation.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/3013
dc.language.isoenen_US
dc.publisherFaculty of Pharmacy, University of Karachien_US
dc.subjectAnti nociceptiveen_US
dc.subjectAnti inflammatoryen_US
dc.subjectAcetic aciden_US
dc.subjectbovine serum albuminen_US
dc.subjectTurraea Vogeliien_US
dc.titleEvaluation of Anti-nociceptive and Anti-Inflammatory Activities of Leaf Extract of Turraea vogelii Hook. f. ex. Benth.en_US
dc.typeArticleen_US

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