Effect of long-term administration of Cinnamomum cassia silver nanoparticles on organs (kidneys and liver) of Sprague Dawley rats

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dc.contributor.authorAdana, M. Y.
dc.contributor.authorKouame, K.
dc.contributor.authorPeter, A. I.
dc.contributor.authorAkang, E. N.
dc.contributor.authorMoodley, R.
dc.contributor.authorNaidu, E. C. S.
dc.contributor.authorAzu, O. O.
dc.date.accessioned2025-05-16T15:36:23Z
dc.date.available2025-05-16T15:36:23Z
dc.date.issued2018
dc.description.abstractThis study investigated the toxic effects of silver on the kidneys and livers of Sprague-Dawley rats after administering multiple doses of silver nanoparticles synthesized using extracts of Cinnamomum cassia (CcAgNPs). Twenty-four Sprague-Dawley rats (250 ± 20 g) were randomly assigned to four groups (A–D) of six animals per group and treated for 8 weeks. Group A was administered 200 mg/kg of Cinnamon Cassia extract (Cc), group B 5 mg/kg of CcAgNPs, group C 10 mg/kg of CcAgNPs, and group D normal saline. Body weight was measured weekly and fasting blood glucose was measured fortnightly. At the end of the experiment, animals were euthanized and organs (livers and kidneys) were fixed in neutral buffered formalin and processed for light microscopy (H&E). Body weight differences were significantly higher (P < 0.05) in the low-dose Cc group and the kidney to body weight ratio was not significant. Renal function analysis of proteins and ketones showed a significant increase in CcAgNP-treated rats (P < 0.05). Kidney and liver histology showed distortions in hepatocytes and sinusoidal linings with infiltrations especially in the higher dose groups. Kidney histology mirrored degenerative changes in glomerular and Bowman’s capsules with fibrillary mesangial interstitium. CcAgNPs impairs renal and hepatic morphology and function after a long period of administration.
dc.identifier.citationKouame, K., Peter, A. I., Akang, E. N., Adana, M. Y., Moodley, R., Naidu, E. C. S., & Azu, O. O. (2018). Effect of long-term administration of Cinnamomum cassia silver nanoparticles on organs (kidneys and liver) of Sprague Dawley rats. Turkish Journal of Biology, 42(6), 498-505, Published by the Scientific and Technological Research Council of Turkey. Available online at https://journals.tubitak.gov.tr/biology/vol42/iss6/ Scopus link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6451848/ (Scopus indexed, Q2)
dc.identifier.issn1303-6092
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16770
dc.language.isoen
dc.publisherScientific and Technological Research Council of Turkey
dc.subjectHistology
dc.subjectnanomedicine
dc.subjecttoxicity
dc.subjectdegenerative
dc.subjectcongestion
dc.titleEffect of long-term administration of Cinnamomum cassia silver nanoparticles on organs (kidneys and liver) of Sprague Dawley rats
dc.typeArticle

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