Effect of Ethanolic Leaf Extract of Senna fistula on some Haematological parameters, lipid profile and oxidative stress in alloxan-induced diabetic rats.

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dc.contributor.authorAyinla M.T
dc.contributor.authorOwoyele, B.V.
dc.contributor.authorYakubu M.T.
dc.date.accessioned2025-05-02T11:26:05Z
dc.date.available2025-05-02T11:26:05Z
dc.date.issued2015
dc.description.abstractSummary: Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. The disease is also known to adversely affect some haematological parameters and cause dyslipidemia. This study was designed to investigate the effectof chronic administration of ethanolic leave extract of Senna fistula on haematological values, oxidative stress and dyslipidemia in experimental diabetic rats. Twenty-four albino rats weighing 120-150 g were divided into 4 experimental groups of six ratseach; control, diabetic untreated, diabetic treated with glibenclamide and diabetic treated with 100 mg/kg b.w of Senna fistula. Diabetes was inducedby 100 mg/kg b.w. of alloxan monohydrates. The control and diabetic groups received normal saline while the diabetic treated groups were administered with 5mg/kg and 100mg/kg body weight of glibenclamide and ethanolic leaves extract of Senna fistula respectively for 28 days. At the end of experimental period blood samples were taken from the animals for the determination of Red blood cells (RBC), packed cell volume (PCV), Haemoglobin concentration (Hb), total cholesterol, triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and malondialdehyde (MDA), marker of lipid peroxidation. The result showed that in diabetic rats, PCV, RBC and Hb were decreased but the application of the extract increased the parameters (P<0.05, n=6). Similarly,the result showed a significant increase in total cholesterol, TG and LDL level of the diabetic group when compared with the control, glibenclamide and extract treated diabetic groups, however, there was no significant difference in HDL level in all the groups. The result also showed a significant decrease inelevated MDA (P<0.05, n=6) of diabetic treated rats. These findings suggest that ethanolic leaves extractof Senna fistula might improvethe diabetic induced disturbances of some haematological parameters, reduces the plasma lipid imbalances and decreases the production of free radicals associated with diabetes.
dc.identifier.citationAyinla, M.T., Owoyele, B.V. & Yakubu, M.T. (2015). Effect of Ethanolic Leaf Extract of Senna fistula on some Haematological parameters, lipid profile and oxidative stress in alloxan-induced diabetic rats. Nigerian Journal of Physiological Sciences. (30); 087-093, Published by Physiological Society of Nigeria. Available on line at: https://ojshostng.com/index.php/njphysiologicalsciences/issue/view/115
dc.identifier.issn0794-859x
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15860
dc.language.isoen
dc.publisherPhysiological Society of Nigeria
dc.relation.ispartofseriesvol 30 no. 1; 087-093
dc.subjectGlibenclamide
dc.subjectSenna Fistula
dc.subjectDiabetes Mellitus
dc.subjectPacked Cell Volume
dc.subjectMalondialdehyde
dc.titleEffect of Ethanolic Leaf Extract of Senna fistula on some Haematological parameters, lipid profile and oxidative stress in alloxan-induced diabetic rats.

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