Immunochemical Evaluation of Biomarkers of Carcinogenesis, Angiogenesis, Neuro-Cancer Interactions and Demyelination in Cadmium Chloride-Induced Testicular Toxicity in Rats.
| dc.contributor.author | Akinlolu, Adelaja | |
| dc.contributor.author | Ameen, Mubarak | |
| dc.contributor.author | Ebito, Gabriel | |
| dc.contributor.author | Asogwa, Nnaemeka | |
| dc.contributor.author | Akindele, Raheem | |
| dc.contributor.author | Fagbohunka, Bamidele | |
| dc.date.accessioned | 2023-07-17T08:17:47Z | |
| dc.date.available | 2023-07-17T08:17:47Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Cadmium is a carcinogen. Neurotransmitter-cancer interaction and tissue-innervation impact cancer survival. This study examined repro-protective and neuro-protective potentials of MO11 (isolated from Moringa oleifera leaves) and MS06 (isolated from Musa sapientum suckers) in cadmium chloride (CdCl2)-induced testicular toxicity. Twenty-four adult male rats were randomly divided into 6 groups. Group 1 was control. Groups 2-4 and 6 received intraperitoneal single-dose of CdCl2 (Day 1). Groups 3, 4 and 6 were post-treated with MO11-dose, MO11+MS06-doses and Doxorubicin-dose respectively, while Group 5 received Olive Oil-dose (vehicle) from Days 1-17. Quantitative tissue enzyme-linked-immunosorbent-assays of biomarkers of carcinogenesis and neuro-cancer interaction in testicular homogenates were evaluated. Data were analysed using Mann-Whitney-U test (p≤0.05). Results showed downregulations of MBP, Caspase-3 and sVEGFR, but upregulations of Dopamine, Glutamate and Cytochrome-p450 in Groups 3, 4 and 6, compared with Group 2. Overall, CdCl2-induced testicular toxicity, angiogenesis and neurocancer interaction were ameliorated by post-treatments with MO11 and MS06. | en_US |
| dc.identifier.issn | 1311-8773 | |
| dc.identifier.issn | 2535-0811 | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/11524 | |
| dc.language.iso | en | en_US |
| dc.publisher | Bulgarian Academy of Sciences | en_US |
| dc.subject | Cadmium | en_US |
| dc.subject | testicular toxicity | en_US |
| dc.subject | drug candidates | en_US |
| dc.subject | neuro-protection | en_US |
| dc.subject | anticancer effects | en_US |
| dc.title | Immunochemical Evaluation of Biomarkers of Carcinogenesis, Angiogenesis, Neuro-Cancer Interactions and Demyelination in Cadmium Chloride-Induced Testicular Toxicity in Rats. | en_US |
| dc.type | Article | en_US |