Physicochemical Properties and Compact analysis of a new Directly Compressible Filler-Binder “Tstarac” and its Utilization in the Formulation of Ascorbic Acid Tablets

Simple item page
dc.contributor.authorShittu, A.O.
dc.contributor.authorAfosi A.B.
dc.date.accessioned2024-05-13T09:41:52Z
dc.date.available2024-05-13T09:41:52Z
dc.date.issued2016
dc.description.abstractAn investigation into the design of a directly compressible filler/binder from two locally available raw materials is hereby reported. „Nigeria tapioca starch‟ (NTS), and „Nigeria acacia sieberiana gum‟ (NASG) were both extracted using standard methods. The resultant materials were passed through mesh 60 and were then coprocessed in isopropanol and water at ratio of 2:1. NTS and NASG were arbitrarily selected at ratio 90:10, 85:15, and 80:20 which gave flow rates of 5.6, 15.1, and 20.6 g/s; angle of repose of 32.3 o, 30.0 o, and 27.5 o. compressibility index was 20.9, 17.3 and 6.0 %; while Hausner ratio was 1.21, 1.16, and 1.06, respectively. The composite containing NTS and NASG (80:20) exhibited the best physicochemical properties and was subsequently selected for the ascorbic acid formulations. It was concluded that the coprocessed NASG and NTS have excellent compressibility and compatibility properties and can serve as cost effective excipients in conventional pharmaceutical solid dosage formulations.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/14130
dc.language.isoen
dc.publisherFaculty of Pharmaceutical Sciences, University of Ilorin
dc.relation.ispartofseries1; 1
dc.titlePhysicochemical Properties and Compact analysis of a new Directly Compressible Filler-Binder “Tstarac” and its Utilization in the Formulation of Ascorbic Acid Tablets
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
4. JPRDP 001 1 - 11 Physicochemical Properties and Compact analysis of a new Directly Compressible Filler-Binder “Tstarac”.pdf
Size:
622.2 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections