Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models

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dc.contributor.authorKadir E.R.
dc.contributor.authorYakub A.D.
dc.contributor.authorOjulari L.S.
dc.contributor.authorHussein A.O.
dc.contributor.authorLawal I.A.
dc.contributor.authorJaji-Sulaimon R.
dc.contributor.authorAjao M.S.
dc.date.accessioned2025-05-08T10:39:42Z
dc.date.available2025-05-08T10:39:42Z
dc.date.issued2024
dc.description.abstractPolycystic ovary syndrome (PCOS) is the most common gynaecological, endocrine disorder that occurs during reproductive age and is a significant cause of anovulatory infertility. Letrozole is an aromatase inhibitor which negates the action of the aromatase enzyme, which results in the buildup of male hormones (testosterone) in the females, causing hyperandrogenism, which is a hallmark of Polycystic Ovarian Syndrome. Mifepristone (RU486) is a progestin antagonist that acts to arrest the actions of the progesterone hormone, resulting in follicular atresia and anovulation. DHEA is an androgen which was also administered in a bid to cause hyperandrogenism in the rats.This study aimed to evaluate the effects of these hormones on the cytoarchitecture of the ovaries and uterus to assess their various PCOS-like histological features.Animals were grouped mainly into three: Letrozole, Mifepristone and DHEA groups, which were further divided into two subgroups each, administered low and high doses of letrozole orally, Mifepristone and Dehydroepiandosterone (DHEA) subcutaneously. Each of the subgroups also had a comparison control group. Following the completion of administration, the Wistar rats were euthanized, and their ovaries and uterus were collected for histological analysis.Increased proliferation of ovarian follicles was noted in the treated groups compared to control, as well as thickening of the endometrial layer.
dc.identifier.citationKadir, E. R., Yakub, A. D., Ojulari, L. S., Hussein, A. O., Lawal, I. A., Jaji-Sulaimon, R., & Ajao, M. S. (2024). Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models. Tissue and Cell. 89. 102456. Published by Elsevier Limited. Available online at https://www.sciencedirect.com/journal/tissue-and-cell/vol/89/suppl/C
dc.identifier.issn1532-3072
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16424
dc.language.isoen
dc.publisherElsevier Limited
dc.relation.ispartofseriesVol 89
dc.subjectHyperandrogenism
dc.subjectAnovulation
dc.subjectCytoarchitecture
dc.subjectProliferation
dc.subjectPCOS
dc.titleCytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models
dc.typeArticle

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