Liver Function Parameters of Diabetic Rats Co-administered with Metformin and Aqueous Leaf Extract of Bryophyllum pinnatum

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dc.contributor.authorO. Soji-Omoniwa
dc.contributor.authorM. O. Oyewole
dc.contributor.authorA. A., Onilude
dc.contributor.authorE. A., Akande
dc.contributor.authorM. P., Falegan
dc.contributor.authorJ. O. Omotayo
dc.contributor.authorR. A., Baba
dc.date.accessioned2024-04-26T09:12:24Z
dc.date.available2024-04-26T09:12:24Z
dc.date.issued2021-07-31
dc.description.abstractThe co-administration of antidiabetic herbs with conventional medicines raises safety concerns due to the complex interactions of multiple bioactive components. This study aimed to assess the impact of co-administering metformin and the aqueous leaf extract of Bryophyllum pinnatum (BPP) on liver function indices of diabetic rats. Forty Wistar rats were divided into five groups of 8 animals each namely; C (Control, distilled water only), DC (Diabetic untreated), Met (120 mg/kg body weight Metformin only), BPP (400 mg.kg b.wt. BPP only), BPP + Met (400 mg/kg b. wt. BPP and 120 mg.kg b.wt. Metformin). Rats were treated for 28 days, sacrificed 24 hours after and their liver and blood collected for the analysis of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, globulin, and total bilirubin. The results revealed a significant increase in total protein and globulin concentrations in the BPP and BPP + Met groups compared to the control (C) group. Conversely, albumin concentration decreased significantly in the diabetic untreated (DC), Metformin (Met), BPP, and BPP + Met groups. Total bilirubin concentration significantly reduced in the BPP + Met group compared to C, DC, and BPP. ALP activity increased significantly in Met, BPP, and BPP + Met groups compared to C, while liver ALP activity showed no significant change. Both serum and liver ALT activities decreased significantly in the experimental groups compared to C. Serum AST activity decreased significantly in Met and BPP + Met groups, while liver AST activity showed significant alterations only in the BPP group. In conclusion, the coadministration of metformin and BPP in diabetic rats did not reverse or improve diabetic-induced liver function indices alterations, suggesting caution in their concurrent use in diabetic condition
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/12948
dc.language.isoen
dc.publisherNigerian Society for Experimental Biology
dc.subjectAminotransferase
dc.subjectAlbumin/globulin ratio
dc.subjectHerb
dc.subjectBryphyllum pinnatum
dc.subjectLiver
dc.titleLiver Function Parameters of Diabetic Rats Co-administered with Metformin and Aqueous Leaf Extract of Bryophyllum pinnatum
dc.typeArticle

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