PHYTOCHEMICAL AND ANTIDIARRHOEAL STUDIES OF THE STEM BARK OF CEIBA PENTANDRA (BOMBACACEAE)

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dc.contributor.authorSule, M.I.
dc.contributor.authorNjinga, N.S.
dc.contributor.authorMusa, A.M.
dc.contributor.authorMagaji, M.G.
dc.contributor.authorAbdullahi, A.
dc.date.accessioned2019-10-30T09:04:47Z
dc.date.available2019-10-30T09:04:47Z
dc.date.issued2009-03
dc.description.abstractCeiba pentandra is a plant commonly used traditionally to treat ailments including diarrhea in Nigeria. The methanolic extract of the stem bark of Ceiba pentandra was studied for its phytochemical constituents and antidiarrhoeal activity using castor oil-induced diarrhea and intestinal transit time models in mice. The phytochemical studies of the methanolic extract revealed the presence of saponins, flavonoids, tannins, terpenes, resins and carbohydrates. The extract showed significant (p< 0.05) protection against castor oil-induced diarrhea at (1000mg/kg) but no significant delay in intestinal transit time was observed. The median lethal dose (LD50) of the methanolic extract was found to be greater than 5000mg/kg which suggested that the extract was non toxic at the antidiarrhoeal dose of 1000mg/kg. The results indicate that the methanolic extract contains compounds with antidiarrhoeal activityen_US
dc.identifier.issn0189-823X
dc.identifier.urihttp://hdl.handle.net/123456789/3121
dc.language.isoenen_US
dc.publisherFaculty of Pharmaceutical Sciences, Ahmadu Bello University Zariaen_US
dc.subjectCeiba pentandraen_US
dc.subjectDiarrhea in Nigeriaen_US
dc.subjectMethanolic extracten_US
dc.titlePHYTOCHEMICAL AND ANTIDIARRHOEAL STUDIES OF THE STEM BARK OF CEIBA PENTANDRA (BOMBACACEAE)en_US
dc.typeArticleen_US

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