Effects of Nigella sativa aqueous extract on some haematological parameters, lipid peroxidation and osmotic fragility changes in alloxan induced diabetic rats

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dc.contributor.authorAyinla M.T
dc.contributor.authorSoladoye, A.O.
dc.contributor.authorOlayaki, L.A.
dc.contributor.authorSuleiman, S.O.
dc.date.accessioned2025-05-02T11:34:35Z
dc.date.available2025-05-02T11:34:35Z
dc.date.issued2010
dc.description.abstractThis study was designed to investigate the effect of extracts of Nigella sativa on some haematological values, lipid peroxidation and osmotic fragility changes in alloxan-induced diabetic rats. Eighteen albino rats were divided into 3 experimental groups of six rats each; control, diabetic untreated, diabetic treated with aqueous extract of Nigella sativa. At the end of experimental period (Four weeks) animals in all the groups were fasted for 12 hours and blood samples were taken for the determination of red blood cell count (RBC), packed cell volume (PCV), Haemoglobin concentration (Hb). In addition Malondialdehyde (MDA, marker of lipid peroxidation) and erythrocytes osmotic fragility test were carried out. In diabetic untreated rats, the PCV, RBC, Hb. were decreased, but application of the extract significantly increased the values (P<0.05, n=6). Similarly, treatment with aqueous extract of Nigella sativa decreased the elevated Malondialdehyde level (P<0.05, n=6) of diabetic rats. The results also showed that Nigella sativa extract significantly reduced the MCF50 from 0.68% to 0.50% (P<0.05 n=6). These findings suggest that Nigella sativa extract might improve the diabetic-induced disturbances of some haematological parameters by decreasing the elevated lipid peroxides and susceptibility of red blood cell to haemolysis.
dc.identifier.citationAyinla, M.T., Soladoye, A.O., Olayaki, L.A. & Suleiman, S.O. (2010). Effects of Nigella sativa aqueous extract on some haematological parameters, lipid peroxidation and osmotic fragility changes in alloxan induced diabetic rats. The Tropical Journal of Health Sciences. 17 (1) 20-24, Published by College of Health Sciences, University of Ilorin, Nigeria. Available on African Journal online. AJOL. https://www.ajol.info/index.php/tjhc/issue/view/7083
dc.identifier.issn2360-879X
dc.identifier.issn1117-4153
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15888
dc.language.isoen
dc.publisherCollege of Health Sciences, University of Ilorin, Nigeria
dc.relation.ispartofseriesvol 17 no. 1; 20-24
dc.subjectNigella sativa
dc.subjectLipid peroxidation
dc.subjectOsmotic fragility
dc.subjectHaematological parameters
dc.subjectMalondialdehyde
dc.titleEffects of Nigella sativa aqueous extract on some haematological parameters, lipid peroxidation and osmotic fragility changes in alloxan induced diabetic rats
dc.typeArticle

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