Effects of 3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(14)-β-D-canaropyranosyl]-17β-marsdenin on selected indices of cardiovascular diseases in mouse
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Date
2022-02
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature
Abstract
Some anticancer pregnane glycosides, e.g., 3-O-[6-deoxy-3-O-methyl-β-d-allopyranosyl-(1 → 4)-β-d-canaropyranosyl]-17β-
marsdenin (3DMACM), have been isolated from Gongronema latifolium leaves which have not been evaluated for their
effects on the cardiovascular system. Thus, this study was carried out to evaluate the effects of 3DMACM on selected indices
of cardiovascular diseases in albino mice. Forty mice were randomly divided into four groups (ten mice each). Group A
mice were orally administered 5% DMSO while mice in groups B, C, and D were orally administered 0.25, 0.5, and 1 mg/
kg body weight of the compound for 14 days, after which various indices of cardiovascular diseases were determined. The
results revealed that the total cholesterol, triacylglycerol, very low density lipoprotein-, and high-density lipoprotein-cholesterol
concentrations in the plasma and heart Na+-
K+-ATPase activity were significantly reduced (p < 0.05) at the doses of 0.25
and 1 mg/kg body weight of the compound compared to controls. Also, atherogenic index, plasma LDH activity, and heart
Mg2+-
ATPase activity of the mice were significantly (p < 0.05) reduced at all doses of the compound compared to controls.
Heart and plasma creatine kinase activities and heart Ca2+-
Mg2+-ATPase activity of mice were significantly (p < 0.05)
reduced at doses higher than 0.25 mg/kg body weight of the compound compared to controls. AST activities in the heart
and plasma of mice were significantly increased (p < 0.05) at doses of 0.25 and 1 mg/kg body weight compared to controls.
The results suggest that 3DMACM may not predispose subjects to atherosclerosis but may adversely affect cardiac muscle
contraction/relaxation, especially at higher doses.
Description
Keywords
Pregnane glycoside · Cardiovascular system · Toxicity · Plant · Muscle contractility
Citation
Adebayo, J.O., Orire, A.B., Gyebi, G.A., Olorundare, O. E., Babatunde, A. S.(2022). Effects of 3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 4)-β-D-canaropyranosyl]-17β-marsdenin on selected indices of cardiovascular diseases in mouse. Comparative Clinical Pathology, 31:155–168.