Anti-inflammatory and Diuretic Activities of Moringa oleifera Lam. (Moringaceae) and Andrographis paniculata Burm. f. (Acanthaceae) Co-administered in Rats.

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dc.contributor.authorLawal, B. A.
dc.contributor.authorSalawu, K. M.
dc.contributor.authorAgunu, A.
dc.contributor.authorAdedoyin, I. R.
dc.contributor.authorAbdulganiy, G. O.
dc.contributor.authorAyanniyi, R. O.
dc.date.accessioned2023-04-11T08:23:40Z
dc.date.available2023-04-11T08:23:40Z
dc.date.issued2016-06
dc.description.abstractMoringa oleifera Lam. ( Moringaceae) and Andrographis paniculata Burm.f. ( Acanthaceae) are commonly used medicine plants in severalparts of Nigeria . The leaf extract of M. oleifera (MO) has been extensively studied and used traditionally for its anti-inflammatory anddiuretic activities. Because of the wide medicinal benefits of these plants they are often used together in polyherbal formulation(s). This study was aimed at evaluating some biological activities of MO and A. paniculata (AP) administered singly and in combination. Thisaim was pursued using in vivo acute toxicity study, formalin induced rat paw edema and diuretic assay. The leaf extracts MO and AP were observed to be safe up to 5000 mg/kg body weight. The extract of MO and AP at 100 mg/kg body weightdisplayed 69.44 and 10.10 % inhibition of rat paw edema respectively, while the combination of extract elicited weaker inhibition (11.29 %)of paw volume. The extract of MO and AP when administered singly and in various combination at different doses elicited similar diureticactivity compared to the hydrochlorothiazide except at a combined dose of MO 50 mg/kg + AP 50 mg/kg, where the urine volume(1.27±0.60 mL) was lower compared to the negative control (1.62±0.52 mL). The extracts of MO and AP were observed to be relatively safe. The extract of MO had significant anti-inflammatory and diuretic activitiescompared to AP . However the combination of both plants extracts led to inhibition of the anti-inflammatory and diuretic activities of MO.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/9037
dc.language.isoenen_US
dc.publisherJournal of Pharmaceutical Research, Development and Practiceen_US
dc.subjectMoringa oleifera, Andrographis paniculata, Combination, Anti-inflammatory, Diuretic activity, Polyherbal formulationen_US
dc.titleAnti-inflammatory and Diuretic Activities of Moringa oleifera Lam. (Moringaceae) and Andrographis paniculata Burm. f. (Acanthaceae) Co-administered in Rats.en_US
dc.typeArticleen_US

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