Evaluation of Nutraceutical content and topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae)

Simple item page
dc.contributor.authorOlumoh-Abdul, H.A
dc.contributor.authorAyanniyi, R.O
dc.contributor.authorOjuade, F.I
dc.contributor.authorAgbana, R.J
dc.date.accessioned2019-10-15T09:46:18Z
dc.date.available2019-10-15T09:46:18Z
dc.date.issued2019-02
dc.description.abstractBackground: Turraea vogelii has been used as traditional medicine for the treatment of ailments including wounds, stomach aches, malaria, infections, filariasis cutaneous, among others and, it serves as source of food. The present study aimed to evaluate the nutraceuticals content and topical anti-inflammatory effect of hydro-methanol twig extract of Turraea vogelii (METV). Method: METV was obtained using cold maceration with water and methanol in ratio 30:70. The concentration of vitamins A, C and E, total phenolic and total flavonoid contents were evaluated by UV spectrophotometric method. Phenol and xylene-induced ear edema was used to evaluate the topical anti-inflammatory effect in mice. Results: The concentration of vitamins A, C and E was found to be 0.113 0.006, 9.303 0.012 and 0.020 0.001 mg in 100g of dried plant materials, respectively. Total phenolic and flavonoid contents were 0.281 0.318 mg/g gallic acid equivalent and 0.112 mg/g quercetin equivalent, respectively. Topical application of METV at a dose of 25 and 50mg/ear in xylene-induced ear edema produced significant inhibition (P<0.05) of 33 and 54% while in phenol-induced ear edema was significantly (P< 0.05) reduced by 44% and 34%. Dexamethasone (0.1mg/ear) produced an inhibition of 83% and 57% in phenol-induced ear edema. Conclusion: Results from this study demonstrated that Turraea vogelii twigs contain flavonoids and phenolic compounds, which may be responsible for the topical anti-inflammatory effect of the plant extract.en_US
dc.description.sponsorshipSelf-fundeden_US
dc.identifier.citationOlumoh-Abdul HA, Ayanniyi RO, Ojuade FI, Agbana RJ (2019). Evaluation of Nutraceutical content and topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae) Iranian Journal of Toxicology. 13(1):35-9.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/2487
dc.language.isoenen_US
dc.publisherIranian Journal of Toxicologyen_US
dc.relation.ispartofseries13(1);35-9
dc.subjectAnti-Inflammatory Effecten_US
dc.subjectDexamethasoneen_US
dc.subjectPhenolen_US
dc.subjectTopicalen_US
dc.subjectTurraea Vogelii Extracten_US
dc.subjectXyleneen_US
dc.titleEvaluation of Nutraceutical content and topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae)en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
IJT-v13n1p35-en.pdf
Size:
235.12 KB
Format:
Adobe Portable Document Format
Description:
Pdf
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections