Phytochemical, Analgesic and Anti-inflammatory Analysis of the Ethylacetate fraction of Paullinia pinnata leaf L. (Sapindaceae).

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dc.contributor.authorAiyelero, Modinat
dc.contributor.authorSalawu, Kayode
dc.contributor.authorYaro, Ah
dc.contributor.authorEnape, OJ
dc.contributor.authorUsman, Sukurat
dc.date.accessioned2019-10-17T11:08:02Z
dc.date.available2019-10-17T11:08:02Z
dc.date.issued2018-05
dc.description.abstractPaullinia pinnata (Sapindaceae) is commonly called sweet gum (English). Traditionally various parts of P. pinnata is used in the management of various diseases including chronic arthritis rheumatic pain. Phytochemical investigation of the ethyl acetate fraction of P. Pinnata leaf showed the presence of flavonoids, saponins, anthraquinone, steroidal terpenoids and carbohydrates only and it was also observed to be non-toxic with LD50 of 1264.9 mg/kg. The fraction displayed significant analgesic activity (21.45, 35.62 and 92.70 % inhibition at 75, 150 and 300 mg/kg body weight respectively) in the formalin induced pain model, whereas ketoprofen had a 28.32 % inhibition of pain. In acetic acid induced writhing model the fraction also displayed significant analgesic activity between 70.03 to 100 % inhibition of the contraction of the abdominal muscle and stretching of the hind limbs at a dose of 75 to 300 mg/kg body weight respectively, where ketoprofen had a 76.60 % inhibition. The fraction had significant anti-inflammatory activity in carrageenan induced paw oedema model with maximum activity up to three hours (60.0 % at first hour, 47.47 % at second hour, 65.38 % at third hour and 63 % at fourth hour) at a dose of 150 mg/kg body weight. The ethyl acetate fraction of P. Pinnata leaf poses significant analgesic and anti-inflammatory activities.en_US
dc.identifier.issn2579-0455
dc.identifier.urihttp://hdl.handle.net/123456789/2677
dc.language.isoenen_US
dc.publisherFaculty of Pharmaceutical Sciences, University of Ilorinen_US
dc.subjectPaullinia pinnataen_US
dc.subjectAcute toxicityen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAnalgesicen_US
dc.titlePhytochemical, Analgesic and Anti-inflammatory Analysis of the Ethylacetate fraction of Paullinia pinnata leaf L. (Sapindaceae).en_US
dc.typeArticleen_US

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