Anti-Ulcerogenic and Toxicological Evaluation of Polyphenol Rich Extract of Cochlospermum Planchonii Roots in Tissues of Aspirin-induced Ulcerogenic Rats

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dc.contributor.authorOyegoke R. A. & Nafiu, M. O
dc.date.accessioned2024-05-08T07:39:38Z
dc.date.available2024-05-08T07:39:38Z
dc.date.issued2024-04-25
dc.description.abstractThe folkloric use of Cochlospermum planchonii roots as an anti-ulcerogenic and its safety is yet to be affirmed with scientific confirmation and this study is designed to do that. This study evaluated the anti-ulcerogenic activity and safety of polyphenol rich extract of Cochlospermum planchonii (PRECPR) roots in aspirin-induced ulcerogenic rats. These roots were processed to give dosages of 50, 100 and 150 mg/kg bodyweight. Thirty rats (138.0 ± 5.0 g) were assigned into six groups. Rats in group A (control) received 1.0 ml of distilled water. Those in groups B – F were administered 200 mg/kg body weight of aspirin and then treated with 1.0 ml of distilled water, 1.0 ml equivalent to 0.05 mg/kg body weight of omeprazole, 50, 100 and 150 mg/kg body weight of PRECPR, respectively. PRECPR dose-dependently increased (p > 0.05) nitric oxide, pH, activities of enzymes, concentrations of bilirubin, creatinine, haematological indices and decreased pepsinogen, volume and acidity of the gastric juice significantly. These results compared favourably (p < 0.05) with those of omeprazole treated group. This study provided strong indication that this extract could serve as an anti￾ulcerogenic agent that is safe Keywords. Anti-ulcerogenic, Cochlospermum planchonii, Polyphenol, Aspirin, Omeprazole.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/13876
dc.language.isoen
dc.publisherUniversity of Tripoli Alahlia-Libya
dc.titleAnti-Ulcerogenic and Toxicological Evaluation of Polyphenol Rich Extract of Cochlospermum Planchonii Roots in Tissues of Aspirin-induced Ulcerogenic Rats
dc.typeArticle

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