Genotoxicity and Ecotoxicological Effects of Cassava Effluent in Swiss Albino Male Mice Using the Sperm Morphology and Peripheral Blood Micronucleus Assays

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dc.contributor.authorAnifowoshe, Abass Toba
dc.contributor.authorIyiola, Oluyinka Ajibola
dc.contributor.authorOlafimihan, Temitope Fatima
dc.contributor.authorOlaoti, Nafisat Bunmi
dc.contributor.authorAkinseye, Kehinde Monica
dc.contributor.authorAbdulkareem, Adam Olaitan
dc.contributor.authorOladipo, Segun Olayinka
dc.date.accessioned2025-04-27T11:56:15Z
dc.date.available2025-04-27T11:56:15Z
dc.date.issued2020
dc.description.abstractCassava is a very important staple food in most developing countries but effluents generated during its processing are not usually disposed properly, thus, contributing significantly to environmental pollution. Several reports have demonstrated the acutely toxic and genotoxic effects of cassava effluent in microbial organisms, plants and aquatic animals, the effects of pollutants present in these effluents have not been clarified yet in terrestrial animals. The study aimed to evaluate the haematological, histopathological and genotoxic potential of cassava effluents from Olorun-Sogo cassava mill in Ilorin, Kwara State, Nigeria, on the male germ and somatic cells of Swiss albino mice using sperm morphology and micronucleus assays. Cassava effluent dilutions of 0.5, 1.0 and 2.0% were administered by intraperitoneal injection to mice, totalizing 0.5mL for 5 consecutive days and a 5 week exposure period was considered. The effluent induced a concentration – dependent statistically significant increase (p< 0.05) in the micronucleus and number of sperm with abnormal morphology at all concentrations as well as diverse histopathological changes in the testes. Haematological parameters were not significantly affected (p>0.05). The liver shows slightly distorted architecture while the kidney shows slight distortion in the renal corpuscles and the surrounding parenchyma. Alterations in alveolar space were observed in the lung while the spleen revealed a slight distortion in it tissue. The physico-chemical analysis also revealed the presence of significant amounts of cyanide and heavy metals (lead, iron, cadmium and silver). The present findings are relevant in environmental waste management and assessment of the hazardous effects of cassava effluents.
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15470
dc.titleGenotoxicity and Ecotoxicological Effects of Cassava Effluent in Swiss Albino Male Mice Using the Sperm Morphology and Peripheral Blood Micronucleus Assays

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