Effect of spinal anaesthesia on QT Interval: Comparative study of severe pre-eclamptic and normotensive parturients undergoing caesarean section.

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dc.contributor.authorAdedapo, A.M
dc.contributor.authorBolaji, B.O
dc.contributor.authorAdegboye, M.B
dc.contributor.authorKolo, P.M
dc.contributor.authorOgunmmodede, J.A
dc.contributor.authorSuleiman, Z.A
dc.contributor.authorAdedapo, O.O
dc.contributor.authorJimoh, O.S
dc.date.accessioned2025-04-29T09:59:51Z
dc.date.available2025-04-29T09:59:51Z
dc.date.issued2022
dc.description.abstractAim: This study aimed to compare the effect of spinal anesthesia on QT interval in severe pre-eclamptic and normotensive parturients who underwent cesarean section in a Nigerian tertiary hospital. Patients and Methods: Twelve-lead electrocardiogram (ECG) was obtained before, and at intervals after spinal anaesthesia on fifty severe pre‑eclamptic (Group A) and fifty normotensive parturients (Group B) who underwent caesarean section. The effect of spinal anaesthesia on QT interval was compared. Results: The preoperative (baseline) mean QT interval was longer in group A than in group B; 453.10 ± 34.11 ms versus 399 ± 18.79 ms, P < 0.001. The prevalence of prolonged QT interval in the severe pre‑eclamptic group before spinal anesthesia was 80% while in the normotensive group it was 0%, P < 0.001. At 5, 30, 60, and 120 min after the establishment of spinal anesthesia, the mean QT interval in the severe pre-eclamptic group was shortened and maintained within normal limits; 414.74 ± 28.05, 418.28 ± 30.95, 411.18 ± 19.21 and 401.36 ± 17.52 ms with P < 0.001 throughout. In the normotensive group, there was no significant change in the mean QT interval. Conclusions: This study demonstrated that the QT interval was more prolonged among the severe pre‑eclamptic parturients. Spinal anesthesia using 0.5% hyperbaric bupivacaine normalized the QT interval and maintained it within normal limits during the study period
dc.identifier.issn2229-7731
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15628
dc.language.isoen
dc.publisherMedical and Dental Consultants Association of Nigeria
dc.subjectBupivacaine
dc.subjectpre‑eclampsia
dc.subjectQT interval
dc.subjectspinal anesthesia
dc.titleEffect of spinal anaesthesia on QT Interval: Comparative study of severe pre-eclamptic and normotensive parturients undergoing caesarean section.
dc.typeArticle

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