Toxicity study of the aqueous extract of Tithonia diversifolia leaves using selected biochemical parameters in rats

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dc.contributor.authorAdebayo, J.O.
dc.contributor.authorBalogun, E.A.
dc.contributor.authorOyeleke, S.A.
dc.date.accessioned2018-03-21T10:01:20Z
dc.date.available2018-03-21T10:01:20Z
dc.date.issued2009
dc.description.abstractTithonia diversifolia has manifold ethnomedicinal uses in traditional settings without much consideration about the possible adverse effects of the consumption of its crude extracts. In this study, effects of repeated oral administration of aqueous extract of Tithonia diversifolia leaves (100 and 200 mg/Kg body weight) for seven days on concentrations of serum electrolytes and biomolecules and the activities of alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in serum, heart, liver and kidney of rats were investigated. The extract significantly increased concentrations of serum calcium ion, potasium ion and HDL-cholesterol but reduced serum albumin concentration at both doses administered compared to controls. At 200 mg/Kg body weight, the extract significantly increased alkaline phosphatase activities in the liver and heart …en_US
dc.identifier.urihttp://hdl.handle.net/123456789/131
dc.language.isoenen_US
dc.subjectExtracten_US
dc.subjectHearten_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectTithonia diversifolia,en_US
dc.subjectToxicityen_US
dc.titleToxicity study of the aqueous extract of Tithonia diversifolia leaves using selected biochemical parameters in ratsen_US
dc.typeArticleen_US

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