Genomic data reveal a north-south split and introgression history of blood fluke populations across Africa

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dc.contributor.authorPlatt,R.N
dc.contributor.authorEnabulele, E.E
dc.contributor.authorAdeyemi, E
dc.contributor.authorAgbugui,M.O
dc.contributor.authorAjakaye, G.O
dc.contributor.authorAmaechi,E.C
dc.contributor.authorEjikeugwu, C.P
dc.date.accessioned2025-04-22T10:18:35Z
dc.date.available2025-04-22T10:18:35Z
dc.date.issued2025-04-13
dc.description.abstractThe human parasitic fluke, Schistosoma haematobium hybridizes with the livestock parasite S. bovis in the laboratory, but the frequency of hybridization in nature is unclear. Here, we analyze 34.6 million single nucleotide variants in 162 samples from 18 African countries, revealing a sharp genetic discontinuity between northern and southern S. haematobium. We find no evidence for recent hybridization. Instead the data reveal admixture events that occurred 257–879 generations ago in northern S. haematobium populations. Fifteen introgressed S. bovis genes are approaching fixation in northern S. haemato bium with four genes potentially driving adaptation. Further, we identify 19 regions that are resistant to introgression; these are enriched on the sex chromosomes. These results (i) suggest strong barriers to gene flow between these species, (ii) indicate that hybridization may be less common than cur rently envisaged, but (iii) reveal profound genomic consequences of rare interspecific hybridization between schistosomes of medical and veterinary importance.
dc.identifier.citationGenome, blood fluke, Africa
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15192
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofseries16; 3508
dc.subjectGenomic data
dc.subjectblood fluke
dc.subjectAfrica
dc.titleGenomic data reveal a north-south split and introgression history of blood fluke populations across Africa

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