Aqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.

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dc.contributor.authorJimoh-Abdulghaffaar, Hidaayah Oluwamayowa
dc.contributor.authorAkintoye, O. O.
dc.contributor.authorAjibare, A. J.
dc.contributor.authorJimoh, O. S.
dc.contributor.authorOwoyemi, J. O.
dc.contributor.authorAnanias, E. N.
dc.contributor.authorIbiyeye, V. O.
dc.contributor.authorAboyeji, A. M.
dc.contributor.authorOjulari, L. S.
dc.date.accessioned2025-05-08T10:26:46Z
dc.date.available2025-05-08T10:26:46Z
dc.date.issued2022-10
dc.description.abstractAqueous extract of Carica papaya leaves was investigated for its acclaimed neuroprotective activity in streptozotocin-induced diabetic peripheral neuropathy in rats. Twenty male, Wistar rats weighing between 120 & 170g were randomly assigned into four groups of five animals each. Rats in group 1 were normal, healthy rats that received normal saline 1.0ml/kg b. w. Those in group 2 (diabetic untreated) received normal saline 1.0ml/kg b. w., group 3 was treated with pregabalin 0.71mg/kg b. w. and group 4 received the aqueous leaf extract of Carica papaya 200mg/kg b. w. Plasma glucose concentration, thermal and mechanical allodynia, and biochemical biomarkers in the brain [malondialdehyde (MDA) and nitric oxide (NO)]; nerve [brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)]; and serum [superoxide dismutase (SOD) and glutathione (GSH)] were assessed. The results showed that the Carica papaya leaf-treated (group 4) rats had a significant fall in the plasma glucose level (p˂0.0001); higher pain threshold on ice cold and von Frey tests (p<0.0001); lower MDA and higher NO, BDNF, NGF, SOD and GSH levels compared to diabetic untreated (p<0.0001) and pregabalin-treated (p<0.0001) rats. Carica papaya leaf extract reduces plasma glucose, mechanical and thermal hyperalgesia, oxidative stress, and nerve damage in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
dc.identifier.citationCarica papaya, Diabetes mellitus, Peripheral neuropathy, Rat, Streptozotocin
dc.identifier.urihttps://www.ajol.info/index.php/ajbr/issue/view/22521
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16403
dc.language.isoen
dc.publisherBiomedical Communications Group, Ibadan, Nigeria
dc.relation.ispartofseries26; 129 - 135
dc.titleAqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
dc.typeArticle

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