Clomiphene Resistant Polycystic Ovarian Syndrome: Analysis of Outcomes following Laparoscopic Ovarian Drilling in Infertile Women in Ilorin, North-Central, Nigeria.

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dc.contributor.authorOmokanye, Lukman O.
dc.contributor.authorOlatinwo, Abdulwaheed O.
dc.contributor.authorPanti, Abubakar A.
dc.contributor.authorIbrahim, S.
dc.contributor.authorOyedepo, O.O.
dc.contributor.authorIge, O.A.
dc.contributor.authorAdegboye, M.B.
dc.date.accessioned2021-05-07T10:04:31Z
dc.date.available2021-05-07T10:04:31Z
dc.date.issued2017
dc.description.abstractBackground: Laparoscopic ovarian drilling (LOD) is one‑off treatment modality for clomiphene citrate (CC)‑resistant polycystic ovarian syndrome (PCOS) avoiding the need of medical therapy and its attendant complications. Aims and Objectives: This study aimed at determining the efficacy of LOD in women with anovulatory infertility secondary to CC‑resistant PCOS and factors influencing reproductive outcomes. Materials and Methods: A cross‑sectional study of infertile women who underwent LOD on account of CC‑resistant PCOS between January 2012 and December 2015 at a tertiary institution. Results: Patients aged 24–38 years (29.7 ± 3.6 years) and their body mass index (BMI) ranges from 20 to 35 (26.3 ± 4.3). The majority (90.5%) were nulliparous. Most (61.3%) had primary infertility. Their duration of infertility ranges from 1 to 13 years (4.3 ± 2.7) and ovarian volume ranges from 10 to 24 cm3 (mean, right ovary = 15.2 ± 3.2; left ovary = 16.3 ± 3.2). The number of drills per ovary ranged from 4 to 14 (mean, right ovary = 7.4 ± 2.1; left ovary = 7.3 ± 2.1) and the luteinizing hormone/follicle stimulating hormone (LH)/FSH ratio ranges from 2 to 6 (3.2 ± 1.4). All achieved spontaneous resumption of menses and ovulation with mean durations of 4.0 ± 1.8 days and 5.3 ± 3.2 weeks, respectively. Eighty‑three (60.6%) clinical pregnancies were recorded, of which 68 (49.6%) resulted to live births (61 singletons and 7 twin births) and 14 (10.2%) early first trimester miscarriages. The mean time interval from LOD to pregnancy was 4.4 ± 1.1 months. There was a significant association between BMI, duration of infertility, FSH/LH ratio, and pregnancy outcomes (P < 0.05). Conclusion: LOD is the most preferred treatment modality for CC‑resistant PCOS as it resulted in higher pregnancy rate.en_US
dc.description.sponsorshipnilen_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5149
dc.language.isoenen_US
dc.publisherAfrican Health Research Organizationen_US
dc.subjectClomiphene citrate- resistanten_US
dc.subjectIlorinen_US
dc.subjectNigeriaen_US
dc.subjectOutcomesen_US
dc.titleClomiphene Resistant Polycystic Ovarian Syndrome: Analysis of Outcomes following Laparoscopic Ovarian Drilling in Infertile Women in Ilorin, North-Central, Nigeria.en_US
dc.typeArticleen_US

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