Genetic Damage, Biochemical and Histopathological Assessment of Mice Exposed to Cypermethrin and Chlorpyrifos

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dc.contributor.authorIyiola, O.A
dc.contributor.authorSulaiman, F.A
dc.contributor.authorAnifowoshe, A.T
dc.contributor.authorAbubakar, F.A
dc.contributor.authorAkolade, J.O
dc.date.accessioned2020-01-30T10:59:14Z
dc.date.available2020-01-30T10:59:14Z
dc.date.issued2019-03-25
dc.descriptionOur results showed that cypermethrin and chlorpyrifos may induce genotoxic in mice at certain concentrations and they should be handled with care to prevent the chemicals being washed into the aquatic environment where they can enter into the food chain and exert serious health effects in living organisms including human via systemic genotoxicity.en_US
dc.description.abstractChlorpyrifos (CPF) and Cypermethrin (CPM) are insecticides widely used in agriculture because of their effectiveness against harmful insects but their toxicity to human is of major concern. This study investigated genotoxic effect of CPF and CPM on some selected organs and tissues of albino mice. Nine (9) male mice were randomly grouped into three and were administered orally with CPF and CPM for five consecutive days and thereafter observed for 30 days. Control group was administered with 0.05ml of distilled water. CPM group was administered with 0.08ml of CPM while CPF group was administered with 0.05ml of CPF. Our results showed that there was a significant increase (p>0.05) in both ALT and AST activity in the serum and liver of both CPF and CPM groups. There was also high concentration of urea, total bilirubin in the serum of both CPF and CPM groups as well as high concentration of glucose in the brain of CPM group. There was no significant increase in the concentration of albumin in the liver of CPF and CPM. Reduction in ALP activity of the liver of both CPF and CPM groups were observed. Cypermethrin induced an increase in abnormal sperm cell shape and shows significant difference when compared to chlopyrifos and negative control. The biochemical alterations observed is consistent with histopathological changes characterized by the appearance of degenerative necrosis, congestion, inflammation and oedema in the liver and kidney of CPM and CPF groups. This study shows that these pesticides are potentially genotoxic to animals and are capable of inducing DNA damage.en_US
dc.identifier.citationIyiola, O. A, Sulaiman, F. A., Anifowoshe A. T., Abubakar, F. A., Akolade J.O. (2019). Genetic Damage, Biochemical and Histopathological Assessment of Mice Exposed to Cypermethrin and Chlorpyrifos " Centrepoint journal (Science edition), University of Ilorin, Accepted on the 25th of March. Vol. 23 (2) Page—149-172. Available online at: http://www.unilorin.du.ng/ejournals/index.php/cp or http://www.centrepointjournal.orgen_US
dc.identifier.urihttp://hdl.handle.net/123456789/3598
dc.language.isoen_USen_US
dc.publisherCentrepoint Journal (Science Edition), Published by University of Ilorin.en_US
dc.subjectcypermethrinen_US
dc.subjectChlorpyrifosen_US
dc.subjectGenetic Damageen_US
dc.subjectHistopathological Assessmenten_US
dc.titleGenetic Damage, Biochemical and Histopathological Assessment of Mice Exposed to Cypermethrin and Chlorpyrifosen_US
dc.typeArticleen_US

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