Neuropharmacological profile of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animals
dc.contributor.author | Ayanniyi, Rashidat | |
dc.contributor.author | Wannang, Noel | |
dc.date.accessioned | 2019-10-18T14:41:09Z | |
dc.date.available | 2019-10-18T14:41:09Z | |
dc.date.issued | 2008 | |
dc.description.abstract | To determine the neuropharmacological activity of the leaf extract of Croton zambesicus in mice and chicks. The effect of aqueous leaf extract of Croton zambesicus on thiopental sodium-induced sleeping time in mice, on gross locomotor activity (GLA) in 2-day old chicks and effect of extract on apomorphineinduced stereotyped behaviour in chicks were evaluated. The aqueous extract (1000 and 1500 mg/kg) administered per os (p.o) prolonged the thiopental sodium-induced sleeping time in mice. Extract (20-40 mg/kg i.p) produced a significant p<0.05 decrease in GLA in 2-day old chicks in a dose dependent manner. 40-60 mg/kg administered intraperitoneally (i.p) produced sedation and sleep with a significant p<0.05 decrease in onset and an increase in duration of sleep. The extract administered subcutaneously (s.c.) had an insignificant p>0.05 effect on apomorphine-induced stereotyped behaviour in chicks. These results suggest that leaf extract of Croton zambesicus possesses CNS depressant, sedative, and hypnotic activity. | en_US |
dc.identifier.uri | http://hdl.handle.net/123456789/2848 | |
dc.language.iso | en | en_US |
dc.publisher | Iranian Journal of Pharmacology and Therapeutics. | en_US |
dc.subject | Croton zambesicus | en_US |
dc.subject | central nervous system | en_US |
dc.subject | depressant | en_US |
dc.subject | sedative | en_US |
dc.subject | hypnotic | en_US |
dc.title | Neuropharmacological profile of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animals | en_US |
dc.type | Article | en_US |
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