Neuropharmacological profile of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animals

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dc.contributor.authorAyanniyi, Rashidat
dc.contributor.authorWannang, Noel
dc.date.accessioned2019-10-18T14:41:09Z
dc.date.available2019-10-18T14:41:09Z
dc.date.issued2008
dc.description.abstractTo determine the neuropharmacological activity of the leaf extract of Croton zambesicus in mice and chicks. The effect of aqueous leaf extract of Croton zambesicus on thiopental sodium-induced sleeping time in mice, on gross locomotor activity (GLA) in 2-day old chicks and effect of extract on apomorphineinduced stereotyped behaviour in chicks were evaluated. The aqueous extract (1000 and 1500 mg/kg) administered per os (p.o) prolonged the thiopental sodium-induced sleeping time in mice. Extract (20-40 mg/kg i.p) produced a significant p<0.05 decrease in GLA in 2-day old chicks in a dose dependent manner. 40-60 mg/kg administered intraperitoneally (i.p) produced sedation and sleep with a significant p<0.05 decrease in onset and an increase in duration of sleep. The extract administered subcutaneously (s.c.) had an insignificant p>0.05 effect on apomorphine-induced stereotyped behaviour in chicks. These results suggest that leaf extract of Croton zambesicus possesses CNS depressant, sedative, and hypnotic activity.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/2848
dc.language.isoenen_US
dc.publisherIranian Journal of Pharmacology and Therapeutics.en_US
dc.subjectCroton zambesicusen_US
dc.subjectcentral nervous systemen_US
dc.subjectdepressanten_US
dc.subjectsedativeen_US
dc.subjecthypnoticen_US
dc.titleNeuropharmacological profile of the aqueous leaf extract of Croton zambesicus (euphorbiaceae) in some laboratory animalsen_US
dc.typeArticleen_US

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