Polymer-Drug Nanoconjugate – An Innovative Nanomedicine: Challenges and Recent Advancements in Rational Formulation Design for Effective Delivery of Poorly Soluble Drugs

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dc.contributor.authorAbioye, Amos Olusegun
dc.contributor.authorChi, George Tangyie
dc.contributor.authorKola-Mustapha, Adeola T
dc.contributor.authorRuparelia, Ketan
dc.contributor.authorBeresford, Ken
dc.contributor.authorAroo, Randolph
dc.date.accessioned2018-08-15T09:03:07Z
dc.date.available2018-08-15T09:03:07Z
dc.date.issued2016
dc.description.abstractBackground: Over the last four decades, the use of water soluble polymers in rational formulation design has rapidly evolved into valuable drug delivery strategies to enhance the safety and therapeutic effectiveness of poorly soluble drugs, particularly anticancer drugs. Novel advances in polymer chemistry have provided new generations of well defined polymeric architectures for specific applications in polymer-drug conjugate design. However, total control of crucial parameters such as particle size, molecular weight distribution, polydispersity, localization of charges, hydrophilic-lipophilic balance and non site-specific coupling reactions during conjugation has been a serious challenge. Objective: This review briefly describes the current advances in polymer-drug nanoconjugate design and various challenges hindering their transformation into clinically useful medicines. Method: Existing literature was reviewed. Results: This review provides insights into the significant impact of covalent and non-covalent interactions between drug and polymer on drug loading (or conjugation) efficiency, conjugate stability, mechanism of drug release from the conjugate and biopharmaceutical properties of poorly soluble drugs. The utility values and application of Quality by Design principles in rational design, optimization and control of the Critical Quality Attributes (CQA) and Critical Process Parameters (CPP) that underpin the safety, quality and efficacy of the nanoconjugates are also presented. Conclusion: It was apparent that better understanding of the physicochemical properties of the nanoconjugates as well as the drug-polymer interaction during conjugation process is essential to be able to control the biodistribution, pharmacokinetics, therapeutic activity and toxicity of the nanoconjugates which will in turn enhance the prospect of successful transformation of these promising nanoconjugates into clinically useful nanomedicines.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1168
dc.language.isoenen_US
dc.publisherPharmaceutical Nanotechnology (Betham Science)en_US
dc.subjectControlled biodistributionen_US
dc.subjectcritical quality attributesen_US
dc.subjectnanoconjugate stabilityen_US
dc.subjectpolymer-drug nanoconjugatesen_US
dc.subjectpoorly soluble drugsen_US
dc.subjectrational formulation designen_US
dc.titlePolymer-Drug Nanoconjugate – An Innovative Nanomedicine: Challenges and Recent Advancements in Rational Formulation Design for Effective Delivery of Poorly Soluble Drugsen_US
dc.typeArticleen_US

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