Cardioprotective Efficacy of Ageratum conyzoides Leaf Extract in Paroxetine-Administered Male Rats
| dc.contributor.author | Muritala Hamdalat Folake1* , Dare Elizabeth Abosede , Alli Abdulhameed Oluwatomi ,Lawal Zainab Bolajoko , Suleiman, Latifat Bukola | |
| dc.date.accessioned | 2026-05-05T11:22:39Z | |
| dc.date.available | 2026-05-05T11:22:39Z | |
| dc.date.issued | 2026-04 | |
| dc.description.abstract | Chronic use of paroxetine, a selective serotonin reuptake inhibitor, is increasingly linked to cardiovascular complications. Owing to safety concerns and the cost of synthetic drugs, plant-based therapies are gaining attention. This study evaluated the cardioprotective potential of Ageratum conyzoides leaf extract (EEACL) via its effects on the Arginase/NO/PDE5 axis and lipid homeostasis. Thirty male Wistar rats were divided into six groups (n=5): naive control, paroxetine-only (10 mg/kg), sildenafil (4 mg/kg), and EEACL treated groups (15, 30, 45 mg/kg). Paroxetine (21 days) significantly (P < 0.05) increased cardiac PDE5 (0.98±0.05 vs 0.78±0.02 mmol/min/mg) and arginase (6.32±0.31 vs 5.35±0.41 mmol/min/mg), reduced NO (61.87±1.36 pg/mL), elevated troponin I (4.72±0.18 pg/mL), and raised total cholesterol (26.33±0.22 mmol/L). Seven-day EEACL treatment reversed these effects. At 45 mg/kg, arginase (5.11±0.22 mmol/min/mg) and troponin I (1.45±0.42 pg/mL) improved, while 15 mg/kg increased NO (72.92±5.29 pg/mL). EEACL at 15 and 30 mg/kg reduced total cholesterol (19.98±3.15; 20.16±1.89 mmol/L) and normalized the atherogenic index (0.09±0.02). These findings suggest A. conyzoides may offer cardioprotection by restoring Arginase/NO/PDE5 balance and lipid stability, supporting its potential as an adjunct therapy for drug-induced cardiotoxicity. | |
| dc.identifier.citation | Muritala et al., 2026 | |
| dc.identifier.issn | eISSN:2708-888X | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/18043 | |
| dc.language.iso | en | |
| dc.publisher | Faculty of Dentistry, Khalij-Libya, Janzour, Libya. | |
| dc.subject | Ageratum Conyzoides | |
| dc.subject | Paroxetine-Administered | |
| dc.subject | Arginase | |
| dc.subject | Phosphodiesterase 5 | |
| dc.subject | Troponin I | |
| dc.subject | Atherogenic Index. | |
| dc.title | Cardioprotective Efficacy of Ageratum conyzoides Leaf Extract in Paroxetine-Administered Male Rats | |
| dc.type | Article |