Identification of Molecular Markers associated with COPD in Non-smokers and Smokers: A Bioinformatics Analysis
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Date
2023
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Journal ISSN
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Publisher
University of Louisville, Kentucky
Abstract
Background: Even though the proportional burden of
chronic obstructive pulmonary disease (COPD) among
never-smokers is significant in both developing and developed
nations, accounting for around 30% of all COPD in
the community, there is little awareness of the prevalence
of COPD in this population. Understanding the molecular
processes that underlie COPD in nonsmokers is essential.
Methods: A dataset (GSE146560) was acquired from
the Gene Expression Omnibus (GEO). The limma and
clusterProfiler software tools were used to identify differentially
expressed genes (DEGs) and conduct a functional
enrichment analysis respectively.
Results: In all, 10,583 DEGswere found, of which 1,065were
up-regulated and 9,518 were down-regulated. Kyoto Encyclopedia
of Genes and Genomes (KEGG) pathways such as
neuroactive ligand-receptor interaction, taste transduction,
maturity onset diabetes of the young, Hippo signaling pathway,
insulin secretion, dilated cardiomyopathy, morphine
addiction, and calcium signaling pathway were mainly enriched
in the DEGs, along with pathways for the Byzantine
arch palate, inflammation, infection, and feeding difficulties.
Conclusion: Particularly downregulated COPD genes,
such FBXL19-AS1, KRTAP5-AS1, and HAGLR antisense, are
identified as COPD biomarkers and may play a role in the
pathogenesis of the illness. However, more investigation is
required to support this study’s conclusions.