Dose related effects of oral clonidine premedication on bupivacaine spinal anaesthesia.

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dc.contributor.authorAdegboye, M.B
dc.contributor.authorKolawole I.K
dc.contributor.authorBolaji B.O.
dc.date.accessioned2025-04-07T09:35:28Z
dc.date.available2025-04-07T09:35:28Z
dc.date.issued2018
dc.description.abstractIntroduction: The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine. Methods: 108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia were randomized into three groups.. Control group A (n=36) no oral clonidine pre-medication, Group B (n=36) and group C (n=36) received 100 μg and 200 μg of oral clonidine pre-medication respectively, 1hr before spinal anaesthesia. Haemodynamic parameters were recorded. Sensory block, degree of motor blockage, and sedation were assessed. Results: Clonidine prolonged the mean duration of motor block by 189.98±26.93 min (100μg) and 191.89±28.13 min (200μg) compared to 117.92±25.13 min in the control group p<0.05. The mean duration of analgesia was 188.19±35 min (100μg) and194±24.58 min (200μg) in the clonidine groups compared to 115.89±26.66 min in control group p<0.05. All the patients were awake in the control group while 71.43% and 100% were drowsy in groups B and C respectively. Conclusion: Oral clonidine produces better clinical effects on the onset and duration of Bupivacaine spinal anaesthesia
dc.identifier.citation6
dc.identifier.issn1729-0503
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/14975
dc.language.isoen
dc.publishercollege of Health Sciences, Makerere University, Uganda
dc.subjectSpinal anaesthesia
dc.subjectpre-medication
dc.subjectclonidine
dc.subjectduration of action
dc.titleDose related effects of oral clonidine premedication on bupivacaine spinal anaesthesia.
dc.typeArticle

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