Synthesis, Characterization and Antimicrobial Activity of Metal (II) Complexes of Mixed Acetylsalicylic acid and 1, 10-phenanthroline

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dc.contributor.authorLawala., A.
dc.contributor.authorShodeinde, A. S.
dc.contributor.authorObaleye, J. A.
dc.contributor.authorBaba, A. A.
dc.date.accessioned2019-10-30T14:16:45Z
dc.date.available2019-10-30T14:16:45Z
dc.date.issued2017-11-20
dc.description.abstractA series of Mn(II), Fe(II), Co(II), Cu(II) and Zn(II) mixed ligands-metal complexes derived from 1,10phenanthroline (PHEN) and acetylsalicylic acid (ASP) have been synthesized. The compounds were characterized using elemental analysis, infrared, ultraviolet/visible spectroscopies and X-ray powder diffraction .The coordination of the two ligands towards the central metal ion has been proposed in the light of elemental analysis, infrared, ultraviolet/ visible, and X-ray powder diffraction spectroscopic studies. The results of the physical and spectroscopic data confirmed that the ligands are bidentate chelating agents. In 1, 10phenanthroline, coordination occurred through the two pyridinic nitrogen groups. Acetylsalicylic acid complexes coordinate through the carbonyl oxygen of the carboxyl and the ester groups. The compounds form a six- coordinate geometry. Antimicrobial activity of the mixed ligand metal complexes and the free ligands were carried out against the bacteria: Escherichia coli, staphylococcus aureus, klebsiella pneumonia, pseudomonas aeruginosa and the fungi candida spp. The mixed ligands metal complexes showed higher activities when compared to the free ligands of acetylsalicylic acid but were less active than the free 1, 10-phenanthroline ligand. The complexes of Mn (II) showed significant antimicrobial activity while the Fe (II) complex exhibited the least activity against the bacteria and fungi organisms.en_US
dc.identifier.issn2408-4840
dc.identifier.urihttp://hdl.handle.net/123456789/3210
dc.language.isoenen_US
dc.publisherFaculty of Physical Sciences, University of Ilorin, Ilorin, Nigeriaen_US
dc.subject1, 10-phenanthrolineen_US
dc.subjectaspirinen_US
dc.subjectcomplexesen_US
dc.subjecttransition metalen_US
dc.subjectspectroscopyen_US
dc.subjectantimicrobialen_US
dc.titleSynthesis, Characterization and Antimicrobial Activity of Metal (II) Complexes of Mixed Acetylsalicylic acid and 1, 10-phenanthrolineen_US
dc.title.alternativeIlorin Journal of Scienceen_US
dc.typeArticleen_US

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