Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria

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dc.contributor.authorOladosu-Olayiwola, Rashidat Oluwatosin
dc.contributor.authorOlawumi, Hannah
dc.contributor.authorBabatunde, Abiola
dc.contributor.authorIjaiya, Munirdeen
dc.contributor.authorDurotoye, Idayat
dc.contributor.authorBiliaminu, Sikiru A
dc.contributor.authorIbraheem, Rasheedat M
dc.date.accessioned2023-01-09T12:18:36Z
dc.date.available2023-01-09T12:18:36Z
dc.date.issued2018
dc.description.abstractBackground: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25th-75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.en_US
dc.identifier.citationOladosu-olayiwola O, Olawumi H, Babatunde A, Ijaiya M, Durotoye I, Biliaminu S, Ibraheem R. Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria. Afri Health Sci. 2018;18(3): 576-583. https://dx.doi.org/10.4314/ahs.v18i3.15en_US
dc.identifier.urihttps://dx.doi.org/10.4314/ahs.v18i3.15
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/8260
dc.language.isoenen_US
dc.titleFibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeriaen_US
dc.typeArticleen_US

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