Antiretroviral drug adverse reactions among HIV-positive patients at a tertiary care hospital in North-Eastern Nigeria

Simple item page
dc.contributor.authorBello, Shakirat Iyabo
dc.contributor.authorDavid, John Ohieku
dc.contributor.authorIkunaiye, Nasiru Y
dc.contributor.authorKida, Ibrahim M
dc.date.accessioned2023-01-05T10:09:18Z
dc.date.available2023-01-05T10:09:18Z
dc.date.issued2020-12
dc.descriptionORIGINAL ARTICLEen_US
dc.description.abstractPurpose: The objective of this study was to evaluate the prevalence of adverse drug reactions (ADRs) among patients on antiretroviral drugs in a tertiary healthcare facility in Maiduguri, NorthEastern Nigeria. Methods: The study was conducted among HIVpositive participants using validated questionnaires and personal interviews to obtain information on ADRs. Participants’ case notes were used to capture data on socio-demographic characteristics, clinical variables, and treatment profiles. The data collected were analyzed with STATA 10 software using logistic regression and descriptive analyses. Results: The prevalence rate of ADRs was 26.6% among 134 patients. Gastrointestinal system disorders 40(8.0%), central and peripheral nervous system 38(7.5%), and systemic signs and symptoms 37(7.3%) were the most common clinical ADRs observed. Zidovudine/Lamivudine/Nevirapine combination therapy was mostly implicated for the ADRs. Logistic regression analysis showed that the occurrence of ADRs was associated with marital status, viral load, and Zidovudine/Lamivudine/Nevirapine therapy. Conclusion: The prevalence of ADRs reported in this study was low. Most of the patients with ADRs had mild effects. Marital status, viral load, and Zidovudine/Lamivudine/Nevirapine contributed to the development of the ADRs. There is a need to closely monitor HIV-infected patients by caregivers to further reduce the prevalence of ADRs and concomitant risks.en_US
dc.description.sponsorshipSELF SPONSORen_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/8143
dc.language.isoenen_US
dc.publisherJournal of Science and Practice of Pharmacyen_US
dc.relation.ispartofseries;7 (1)
dc.subjectAntiretroviralsen_US
dc.subjectdolutegraviren_US
dc.subjectgastrointestinal systemen_US
dc.subjecthuman immunodeficiency virusen_US
dc.titleAntiretroviral drug adverse reactions among HIV-positive patients at a tertiary care hospital in North-Eastern Nigeriaen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
26 UNIBEN PAPER ADR.pdf
Size:
487.31 KB
Format:
Adobe Portable Document Format
Description:
MAIN ARTICLE
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections