Comparing perioperative vaginal misoprostol with intraoperative pericervical hemostatic tourniquet in reducing blood loss during abdominal myomectomy: A randomized controlled trial.

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dc.contributor.authorAfolabi, Muhibat
dc.contributor.authorEzeoke, Grace
dc.contributor.authorSaidu, Rakiya
dc.contributor.authorIjaiya, Munirdeen
dc.contributor.authorAdeniran, Abiodun
dc.date.accessioned2019-10-22T09:58:40Z
dc.date.available2019-10-22T09:58:40Z
dc.date.issued2019
dc.description.abstractObjective: To compare the effectiveness of perioperative vaginal misoprostol with intraoperative pericervical hemostatic tourniquet in reducing blood loss during abdominal myomectomy. Material and Methods: A randomized controlled trial involving women with uterine leiomyoma who underwent abdominal myomectomy was conducted at a tertiary facility in Nigeria. Participants were recruited after they gave informed consent and randomized into group I (single dose 400 μg vaginal misoprostol one-hour before surgery) and group II (intraoperative pericervical hemostatic tourniquet). Eighty participants (40 in each group) were recruited. Uterine size was measured in centimeters above the pubic symphysis, and blood loss estimation involved direct volume measurement and gravimetric methods. The main outcome measures were intraoperative blood loss, blood transfusion, and recourse to hysterectomy. Ethical approval and trial registration were obtained; the data were analyzed using the SPSS software version 21.0; p<0.05 was considered significant. Results: Participants in group I had higher mean intraoperative blood loss (931.89±602.13 vs 848.40±588.85 mL, p=0.532), intra-operative blood transfusion rates (60 vs 55%; p=0.651) and mean units of blood transfused (1.30±1.20 vs 1.20±1.30; p=0.722) compared with group II. The mean uterine size (19.50±6.93 vs 20.05±6.98 cm; p=0.725) and number of fibroid nodules (11.25±7.99 vs 11.45±8.22; p=0.912) were comparable. The change in post-operative hematocrit was 2.66±2.21% vs 3.24±2.85% (p=0.315) and post-operation blood transfusion was 2.5 vs 5% (p=0.556). There was no recourse to hysterectomy in either of the study groups. While adverse effects of misoprostol occurred in 5 (12.5%) participants of group I. Conclusion: The effectiveness of perioperative vaginal misoprostol is comparable to intra-operative hemostatic pericervical tourniquet in reducing blood loss during abdominal myomectomy. (J Turk Ger Gynecol Assoc 2019; 20: 23-30)en_US
dc.description.sponsorshipNilen_US
dc.identifier.otherDOI: 10.4274/jtgga.galenos.2018.2018.0049
dc.identifier.urihttp://hdl.handle.net/123456789/3045
dc.language.isoenen_US
dc.publisherTurkish-German Gynecological Associationen_US
dc.subjectUterine leiomyomaen_US
dc.subjectMisoprostolen_US
dc.subjectHemostatic tourniqueten_US
dc.subjectAbdominal myomectomyen_US
dc.subjectHemostasisen_US
dc.titleComparing perioperative vaginal misoprostol with intraoperative pericervical hemostatic tourniquet in reducing blood loss during abdominal myomectomy: A randomized controlled trial.en_US
dc.typeArticleen_US

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