Effects of acetone extract of Cola nitida on memory and brain glutamate receptors in female Wistar rats

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dc.contributor.authorImam-Fulani, Aminat Omolola
dc.contributor.authorOlajide, Lateefah O
dc.date.accessioned2023-05-05T13:24:25Z
dc.date.available2023-05-05T13:24:25Z
dc.date.issued2021-12-31
dc.description.abstractCola nitida is the seed of the Kola tree which is commonly grown in the tropical rainforest of Africa. It has been in vogue use for its caffeine and many other beneficial contents such as the obromine. This study aims to investigate the effects of acetone extract of Cola nitida on memory, plasma aspartate aminotransferase activity and metabotropic glutamate receptor 1a in female Wistar rats. Fifteen female Wistar rats were used and grouped into three. Control was given 1.2ml normal saline, low dose group was administered 50mg/kg body weight (bw) of Cola nitida extract and high dose group was administered 100mg/kg bw. Memory and cognition tests were evaluated using Morris water maze, Y-maze and using novel object recognition test. Plasma lactate dehydrogenase and aspartate amino transferase levels were estimated and immunohistochemical analysis of the hippocampus and amygdala was observed. There was significant (p<0.05) decrease in duration to get the escape platform in high dose group compared to control in the Morris water maze test. Also, there was a significant (p<0.05) increase in aspartate aminotrannsferase level in the group administered low dose of the extract of Cola nitida. Avivid stimulation of the glutamate receptors was observed following immunohistochemical analysis. In conclusion, Cola nitida enhance memory in female Wistar rats through the stimulation of glutamate receptors and increase in plasma aspartate glutamate receptors and increase in plasma aspartate aminotrannsferase level.en_US
dc.identifier.citation28(4)en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/9494
dc.language.isoenen_US
dc.publisherAfrican Journals Onlinesen_US
dc.relation.ispartofseries;28(4)
dc.subjectCola nitidaen_US
dc.subjectglutamate receptorsen_US
dc.subjectimmunohistochemistryen_US
dc.subjectWistar ratsen_US
dc.subjecthippocampusen_US
dc.subjectamygdalaen_US
dc.titleEffects of acetone extract of Cola nitida on memory and brain glutamate receptors in female Wistar ratsen_US
dc.typeArticleen_US

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