Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.
dc.contributor.author | Hamid, A. A. | |
dc.contributor.author | Negi, A. S. | |
dc.contributor.author | Zubair, M. F. | |
dc.contributor.author | Oguntoye, S. O. | |
dc.contributor.author | Aiyelaagbe, O. O | |
dc.date.accessioned | 2018-02-22T08:51:04Z | |
dc.date.available | 2018-02-22T08:51:04Z | |
dc.date.issued | 2015 | |
dc.description.abstract | Ethyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 μg/mL respectively. Isolation of the extracts afforded Tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), β-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, ID and 2D NMR and Mass spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with IC50 of 57.27 and 27.56 μg/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF-7 tumor cell lines. | en_US |
dc.description.sponsorship | University of Ilorin, Nigeria. CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India. TWAS-CSIR | en_US |
dc.identifier.citation | CPJ 2015001/21101 | en_US |
dc.identifier.issn | 2141-3819 | |
dc.identifier.uri | http://hdl.handle.net/123456789/108 | |
dc.language.iso | en | en_US |
dc.publisher | University of Ilorin | en_US |
dc.relation.ispartofseries | Volume 21, No. 1,;1-12 | |
dc.subject | Turraea vogelli, | en_US |
dc.subject | ethyl tridec-7-enoate | en_US |
dc.subject | stigmasterol, | en_US |
dc.subject | β-sitosterol, | en_US |
dc.subject | antiproliferative activity, | en_US |
dc.title | Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves. | en_US |
dc.type | Article | en_US |
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