Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.

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dc.contributor.authorHamid, A. A.
dc.contributor.authorNegi, A. S.
dc.contributor.authorZubair, M. F.
dc.contributor.authorOguntoye, S. O.
dc.contributor.authorAiyelaagbe, O. O
dc.date.accessioned2018-02-22T08:51:04Z
dc.date.available2018-02-22T08:51:04Z
dc.date.issued2015
dc.description.abstractEthyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 μg/mL respectively. Isolation of the extracts afforded Tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), β-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, ID and 2D NMR and Mass spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with IC50 of 57.27 and 27.56 μg/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF-7 tumor cell lines.en_US
dc.description.sponsorshipUniversity of Ilorin, Nigeria. CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India. TWAS-CSIRen_US
dc.identifier.citationCPJ 2015001/21101en_US
dc.identifier.issn2141-3819
dc.identifier.urihttp://hdl.handle.net/123456789/108
dc.language.isoenen_US
dc.publisherUniversity of Ilorinen_US
dc.relation.ispartofseriesVolume 21, No. 1,;1-12
dc.subjectTurraea vogelli,en_US
dc.subjectethyl tridec-7-enoateen_US
dc.subjectstigmasterol,en_US
dc.subjectβ-sitosterol,en_US
dc.subjectantiproliferative activity,en_US
dc.titleChemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.en_US
dc.typeArticleen_US

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