ARE ANTIBIOTICS OF ANY USE IN THE MANAGEMENT OF GRANULOMA ANNULARE IN CHILDREN?

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dc.contributor.authorGermaine, Chia
dc.contributor.authorLeila, Ahmed
dc.contributor.authorPeter, Oligbu
dc.contributor.authorLouis, Odeigah
dc.contributor.authorGodwin, Oligbu
dc.date.accessioned2021-12-16T11:27:43Z
dc.date.available2021-12-16T11:27:43Z
dc.date.issued2019
dc.description.abstractBackground: Granuloma annulare (GA) is a benign inflammatory dermatosis of unknown cause, of which generalised granuloma annulare (GGA) is a subtype that tends to be resistant to treatment. Various antibiotics have been used to treat GGA, the most recent being combination therapy with rifampicin, ofloxacin and minocycline (ROM). This study aims to explore the efficacy of antibiotics in treating GGA, and whether antibiotics may be useful in children with GGA. Materials and Methods: A systematic review of literature published from 1947 to 2017 was undertaken in order to evaluate the use of antibiotics in treating GGA. Data on characteristics of children with GGA were extracted and eligible studies were then qualitatively analysed. Results: Seven hundred and ninety (790) potential studies were identified, of which 16 were eligible for inclusion in the final analysis. Of these 16 studies, majority were case studies (n=9, 56.3%), with 2 case series (12.5%), 2 retrospective studies (12.5%) and 3 open-label prospective studies (18.8%). Main antibiotic treatments reported were either monthly combination therapy of rifampicin, ofloxacin and minocycline (ROM), or monotherapy with dapsone or doxycycline. Out of a total of 158 patients with GA, 72 patients (45.6%) were treated with antibiotics. Of the 72, 48.6% (n=35) of these patients had GGA while 4 were children; two with GA (2 with GGA), all of whom were treated with dapsone. Conclusion: There is paucity of evidence to support the use of antibiotics in the treatment of GGA in children. Although ROM has shown promising results in adults, more studies are needed to validate these findings in children.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7190
dc.language.isoenen_US
dc.publisherLondon North West Healthcare NHS Trust, London, UK, 2 Department of Family medicine, University of Benin Teaching Hospital, Benin City, Nigeria, 3 Department of Family Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria, 4 Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's, University of London, UK.en_US
dc.subjectgranuloma annulareen_US
dc.subjectgeneralised granuloma annulareen_US
dc.subjectantibioticsen_US
dc.subjectchildrenen_US
dc.subjectoutcomeen_US
dc.titleARE ANTIBIOTICS OF ANY USE IN THE MANAGEMENT OF GRANULOMA ANNULARE IN CHILDREN?en_US
dc.typeArticleen_US

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