Long-Term Effect of HAART on Biochemical Profiles of HIV/AIDS Patients in a Tertiary Health Facility in Benin City, Nigeria

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dc.contributor.authorBello, Shakirat I.
dc.contributor.authorOnunu, Abel N
dc.contributor.authorErah, Patrick O.
dc.date.accessioned2018-08-16T12:30:27Z
dc.date.available2018-08-16T12:30:27Z
dc.date.issued2014-11
dc.description.abstractPurpose: To assess the long-term effect of highly active antiretroviral therapy (HAART) on biochemical parameters of HIV-infected patients in University of Benin Teaching Hospital (UBTH), Benin City, Nigeria. Methods: HIV/AIDS patients on HAART for 2 - 8 years (297), those who were not on HAART (112, positive control), and healthy subjects (103, negative control) were recruited in the Infectious Diseases Clinic (IDC) of UBTH. Their sera were assayed for biochemical parameters. WHOQoL bref instrument was used to assess patients’ Quality of life (QoL). Results: Patients who have been on HAART had significantly elevated ALT and AST levels (p < 0.001) but mild liver toxicity. QoL of these patients was not significantly different from that of the healthy controls. The levels of Na+ (133.4 ± 5.2 mmol/l), K+ (3.6 ± 0.4 mmol/l) and Cl- (101.3 ± 4.0 mmol/l) were significantly lower in patients on HAART than those of the positive (137.5 ± 5.1, 3.9 ± 0.5, 104.3 ± 5.7 mmol/l respectively, p < 0.001). Also, levels of creatinine (0.8 ± 0.2 mg/dl), TBil (0.5 ± 0.2 mg/dl), and CB (0.3 ± 0.5 mg/dl) were significantly higher in patients on HAART than those of either the positive (0.7 ± 0.3, 0.4 ± 0.2, 0.2 ± 0.1 mg/dl) or negative (0.7 ± 0.3, 0.3 ± 0.1, 0.2 ± 0.1 mg/dl) controls respectively (p < 0.001). Conclusion: Treatment with HAART for 2 - 8 years may not produce severe hepatotoxicity in HIV/AIDS patient though mild liver toxicity should be expected. The patients’ QoL was not negatively affected by the use of HAART for 2 - 8 years.en_US
dc.description.sponsorshipSELFen_US
dc.identifier.issn1596-5996
dc.identifier.urihttp://hdl.handle.net/123456789/1182
dc.language.isoenen_US
dc.publisherPharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeriaen_US
dc.subjectBiochemical parametersen_US
dc.subjectHIV/AIDSen_US
dc.subjectLong-term HAARTen_US
dc.subjectQuality of Lifeen_US
dc.titleLong-Term Effect of HAART on Biochemical Profiles of HIV/AIDS Patients in a Tertiary Health Facility in Benin City, Nigeriaen_US
dc.typeArticleen_US

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