Cypermethrin and chlorpyrifos raises serum urea level and causes abnormal sperm morphology in Wistar rats

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dc.contributor.authorIyiola, Oluyinka Ajobola
dc.contributor.authorSulaiman, A.F
dc.contributor.authorSulaiman, Abdulfattah Afolabi
dc.contributor.authorAnifowoshe, Abass Toba
dc.contributor.authorAkolade, Jubril Olayinka
dc.contributor.authorAdisa, Muhammad Jamiu
dc.contributor.authorOtohinoyi, D.A
dc.contributor.authorRotimi, Damilare E.
dc.contributor.authorBatiha, Gaber El-Saber
dc.contributor.authorMaimako, Rotdelmwa Filibus
dc.contributor.authorAdeyemi, O.S
dc.date.accessioned2020-01-30T11:33:23Z
dc.date.available2020-01-30T11:33:23Z
dc.date.issued2019
dc.descriptionFindings indicate that cypermethrin and chlorpyrifos exposure in rats predisposes to renal injury. Additionally, exposure to cypermethrin and chlorpyrifos altered rat sperm morphology. Taken together, the findings suggest caution in the application of these pesticides, particularly for domestic purposes.en_US
dc.description.abstractChlorpyrifos (organophosphate) and cypermethrin (pyrethroid) are insecticides, which are widely used for agricultural as well as for domestic purposes. This study investigated the toxicological effect of chlorpyrifos and cypermethrin on selected organs and tissues of male Wistar rats. Nine (9) male Wistar rats were randomly grouped into three and were orally given chlorpyrifos or cypermethrin, while the control group was given distilled water for 28 days. The results revealed a significant increase (p<0.05) in rat serum AST activity for the chlorpyrifos and cypermethrin groups. Also, there was significant elevation in serum urea following oral exposure to either chlorpyrifos or cypermethrin. Conversely, a reduction in the rat liver ALP activity for treatment with cypermethrin or chlorpyrifos was recorded. The histology results revealed that the administration of chlorpyrifos but not cypermethrin for 28 days has no significant effect on the biochemical properties and sperm morphology of the rats. Taken together, findings indicate that cypermethrin and chlorpyrifos exposure in rats predisposes to renal injury, while altering sperm morphology.en_US
dc.identifier.citationIyiola, Oluyinka Ajobola, Sulaiman, A. F. and Sulaiman, Abdulfattah Afolabi, Anifowoshe, Abass Toba, Akolade, Jubril Olayinka, Adisa, Muhammad Jamiu, Otohinoyi, D. A., Rotimi, Damilare E., Batiha, Gaber El-Saber, Maimako, Rotdelmwa Filibus, Adeyemi, O. S. (2019). Cypermethrin and chlorpyrifos raises serum urea level and causes abnormal sperm morphology in Wistar rats. Biointerface Research in Applied Chemistry, 9 (3). pp. 3969-3973. ISSN 2069-5837. Available online at http://eprints.lmu.edu.ng/2209/en_US
dc.identifier.issn2069-5837
dc.identifier.urihttp://hdl.handle.net/123456789/3618
dc.language.isoen_USen_US
dc.publisherBiointerface Research in Applied Chemistryen_US
dc.subjectbiochemical toxicologyen_US
dc.subjectreproductive biochemistryen_US
dc.subjectmedicinal biochemistryen_US
dc.subjectpesticidesen_US
dc.titleCypermethrin and chlorpyrifos raises serum urea level and causes abnormal sperm morphology in Wistar ratsen_US
dc.typeArticleen_US

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