Cardiac autonomic dysfunction in sickle cell anaemia and its correlation with QT parameters.

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dc.contributor.authorKolo, PM
dc.contributor.authorSanya, EO
dc.contributor.authorOlanrewaju, TO
dc.contributor.authorFawibe, AE
dc.contributor.authorSoladoye, A
dc.date.accessioned2023-07-11T10:10:08Z
dc.date.available2023-07-11T10:10:08Z
dc.date.issued2013
dc.description.abstractBackground: Abnormalities of QT parameters together with cardiac autonomic neuropathy (CAN) confer significant risks of cardiac morbidity and mortality in patients with diabetes mellitus. We questioned whether or not CAN influences occurrence of QT interval prolongation and dispersion in patients with sickle cell anaemia (SCA). Materials and methods: Forty stable adult sickle cell patients with 44 healthy haemoglobin AA controls were studied. Baseline electrocardiograms were obtained and cardiovascular autonomic function tests were performed using standard protocols. Results: Mean corrected QT (QTc) in sickle cell patients was significantly higher (P = 0.001) than the mean of controls. Similarly, mean QT dispersion (QTcd) was higher (P = 0.001) in the former than in the latter. Mean QTc in patients with CAN was longer than patients with normal autonomic function (461 ± 26 ms versus 411 ± 23 ms), P = 0.001 (OR of 17.1, CI 3.48-83.71). Similarly, QTcd was higher (P = 0.001) in patients with CAN than those with normal cardiac autonomic function. Positive correlations were found between CAN with QTc and QTcd (r = 0.604, P = 0.001, r = 0.523, P = 0.001, respectively). Conclusion: CAN is a risk factor for abnormalities of QT parameters in SCA and both may be harbinger for cardiac death.en_US
dc.identifier.citationKolo PM, Sanya EO, Olanrewaju TO, Fawibe AE, Soladoye A. Cardiac autonomic dysfunction in sickle cell anaemia and its correlation with QT parameters. Niger Med J. 2013 Nov;54(6):382-5. doi: 10.4103/0300-1652.126288. PMID: 24665151; PMCID: PMC3948959.en_US
dc.identifier.otherhttps://doi.org/10.4103/0300-1652.126288
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11436
dc.language.isoenen_US
dc.publisherNigerian Medical Association.en_US
dc.subjectCardiac arrhythmias; QTc; cardiac autonomic neuropathy; sickle cell anaemia.en_US
dc.titleCardiac autonomic dysfunction in sickle cell anaemia and its correlation with QT parameters.en_US
dc.typeArticleen_US

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