Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats.

Simple item page
dc.contributor.authorAyinde, T.O.,
dc.contributor.authorOjulari, L.S.,
dc.contributor.authorAfodun, A.M.,
dc.contributor.authorBalogun, M.E.,
dc.contributor.authorFaramade, A.A.,
dc.contributor.authorRaji, A.O.,
dc.contributor.authorLiadi, M.T.,
dc.contributor.authorBelewu, M.A.
dc.date.accessioned2024-04-23T14:22:30Z
dc.date.available2024-04-23T14:22:30Z
dc.date.issued2022
dc.description.abstractCaffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.
dc.identifier.citationCaffeine, Creatinine, Urinalysis, Renal function, Urea, Electrolytes
dc.identifier.issn2354 1784
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/12663
dc.language.isoen
dc.publisherSociety for the Conservation of Phytofuels and Sciences.
dc.relation.ispartofseries11(1); ; 45-53.
dc.titleEffect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats.
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Phytofuels journal effect-of-chronic-administration-of-caffeine-on-renal-function-in-male-wistar-rats.pdf
Size:
694.1 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections