Ayinla M.TOwoyele, B.V.Yakubu, M.T.Biliamin, S.A.2025-05-032025-05-032019Ayinla, M.T., Owoyele, B.V., Yakubu, M.T. & Biliamin, S.A. (2019): Antihyperglyceamic effects of aqueous leaf extract of Senna fistula in streptozotocine-induced diabetic rats. Pacific Journal of Medical Sciences. 20(1); 19-29, Published by School of Medicine and Health Sciences, University of Papua New Guinea, available online at https://www.pacjmedsci.com/pjms-vol-20-no-1-nov-20192072-1625https://uilspace.unilorin.edu.ng/handle/123456789/16007This study investigated antihyperglycemic effects of chronic administration of aqueous leaf extract of Senna fistula in Streptozotocin-induced diabetic rat. Thirty rats were randomly assigned into six groups (A-F). Animals in group A were the control non-diabetic, in group B were diabetic and received distilled water, in group C were diabetic, treated with 2.5 mg/kg body weight of Glibenclamide, while animals in groups D, E and F were diabetic treated with 28.57, 57.14 and 114.28 mg/kg body weight respectively of aqueous leaf extract of Senna fistula for 28 days. At the end of 28 days blood samples were collected for the assay of Insulin, Superoxide Dismutase, Catalase, and Glutathione Peroxidase in serum and liver Glycogen. The result showed that the blood glucose levels of diabetic rats were significantly reduced in the extract and Glibenclamide treated animals when compared with diabetic rats that received distilled water. Similarly, there was a significant increase in serum Insulin level, Superoxide dismutase, Catalase and Glutathione peroxidase activities and liver glycogen in the extract and Glibenclamide treated diabetic groups when compared with diabetic untreated group. The results indicated that oral administration of aqueous extract of Senna fistula has antihyperglycemic effect by stimulating Insulin secretion and activating antioxidant enzymes.enInsulinSuperoxide dismutaseSenna fistulaGlibenclamideAntioxidantArticle