Aiyelero, O.M.Olumoh-Abdul, H.AOjuade, F.I.Yaro, A.H.Muhammad, Z.2023-05-092023-05-0920222579-0455https://uilspace.unilorin.edu.ng/handle/20.500.12484/9763Lannea acida is a medicinal plant used for the treatment of a wide range of ailments including haemorrhoid. In the present study, the phytochemical constituents present in the methanol stem bark extract of Lannea acida were determined using standard protocol. The analgesic and anti-inflammatory activities of the extract were evaluated. Acetic acid-induced writhing and hot plate-induced tests in mice were used to evaluate the analgesic activity, while Egg albumin-induced paw edema in rats was used to evaluate the anti-inflammatory activity. Median lethal dose of the extract was estimated using Lorke’s method. For each of the tests, thirty animals were divided into five groups of six mice each. Groups I – V received normal saline (10 ml/kg), Lannea acida extract (20, 40, and 80 mg/kg i.p.), and piroxicam (20 mg/kg) for acetic acid induced writhes/egg albumin-induced paw edema and pentazocine (20 mg/kg) for hot plate induced pain tests respectively. The phytochemical screening revealed the presence of carbohydrates, flavonoids, glycosides, alkaloids, saponins and tannins. The intraperitoneal LD50 value in mice was estimated to be 282.8mg/kg. The extract significantly (P<0.05) inhibited acetic acid-induced writhing and also produced more than 70% inhibition at all tested doses after 1 hour against thermal-induced pain in mice. The extract at all tested doses afforded 64% inhibition of paw edema at the end of the 4th hour. The result obtained lends the credence to the ethnomedical use of the plant in the management of haemorrhoids.enAnalgesic, Anti-inflammatory, Acetic acid, Lannea acida, painArticle