Shittu, A.O.Oyi A.R.Onaolapo, J.A.2024-05-132024-05-132010https://uilspace.unilorin.edu.ng/handle/123456789/14114The effect of increasing concentrations of a locally sourced A. sieberiana gum on the granules and tablet properties of chloroquine and metronidazole tablets was investigated in the gum matrix formulation. Varying concentrations 10-60%w/v of A. sieberiana gum composition in the tablet formulation was evaluated. Matrix tablets were formulated via the wet granulation method with 5%w/v maize starch mucilage as binder and at compression pressure of 3.5 x 105 N/m2. Mean granule size was greater than 500m. Flow properties of granules were optimal with average of 4.1g/sec for chloroquine phosphate matrix and 3.5g/sec for metronidazole matrix. Tablets prepared revealed that 50%w/w composition of gum produced the best quality in terms physico mechanical properties base friability, crushing strength and weight variation. Dissolution rate studies revealed T 90% for metronidazole matrix tablet and chloroquine phosphate matrix tablet as 1hr 45min and 50 min respectively. The gum shows better retardant effect with metronidazole than chloroquine phosphateenAcacia sieberiana gumMatrix granulesMatrix tabletsArticle