Adeniran A.S.Kadir R.E.Balogun O.R.2025-04-292025-04-292013Adeniran A.S., Kadir R.E. & Balogun O.R. (2013): Pregnancy outcome in booked Nigerian sickle cell disease patients. (2012): Nigerian Research Journal of Clinical Sciences. 2(2):93-100. Erratum in Nigerian Research Journal of Clinical Sciences. 2013;3(1):60 Eniola KR [corrected to Kadir ER]. Published by Faculty of Clinical Sciences, Delta State University, Abraka, Nigeria2276-6995https://uilspace.unilorin.edu.ng/handle/123456789/15631Background: As sickle cell disease patients now survive to reproductive age, their pregnancies and outcome remain a concern to obstetricians in view of the higher risk for complications. Objective: To determine pregnancy outcome in sickle cell disease patients who had antenatal care and compare this with outcome in age and parity matched non sickle cell disease controls that had antenatal care. Setting: The study was conducted at the Obstetrics and Gynaecology Department of the University of Ilorin Teaching Hospital (UITH), Ilorin, Kwara State, Nigeria. Methodology: A five year retrospective case control study involving all sickle cell disease women who had antenatal carenand subsequently delivered at the study site from 1st January 2007 to 31st December 2011 and age and parity matched non sickle cell pregnant women who also had antenatal care at the study site as controls. Data was collected from the individual patient case files and analysed using SPSS version 18. Results: The incidence of of sickle cell disease (SCD) was 0.51% with mean age 28.2+-2.41 years, mean parity 2.1+-0.62, mean height 161+-0.58cm and mean weight 58.2+-3.12kg. Educational attainment was higher among SCD (subjects) compared to controls (P=0.044). Subjects had higher percentages of all complications in pregnancy and delivery than controls; if these, maternal anaemia, miscarriage and forceps delivery were statistically significant while urinary tract infections, malaria in pregnancy, preterm delivery, caeserean delivery and postpartum haemorrhage were not significant. Neonatal outcomes were poorer among subjects but these were not statistically significant. The perinatal mortality rates were 178.6/1000 for subjects and 107.1/1000 among controls. Maternal mortality was 5.4% among subjects and none among controls. Conclusion: Pregnancy outcomr was poorer in sickle cell disease women compared to non sickle cell controls despite antenatal care; however, majority of these were not statistically significant. Maternal mortality remained relatively relatively higher despite antenatal care in SCD women similar to other reports from low income countries.enSickle cell diseasePregnancyOutcomeAntenatal careArticle