AIYELERO, OYERONKE MEDINATOJUADE, FATIMOH IDOWUABDUL-OLUMOH, HIDAYAH AYODEJIIBEGBUNAM, CHISOM OLIVIAAYANNIYI, RASHIDAT OLUWAFUNKE2023-04-262023-04-2620220794-800Xhttps://uilspace.unilorin.edu.ng/handle/20.500.12484/9299Clerodendrum volubile is used for the local management of fluid retention or edema. This present study aimed to evaluate the diuretic activity of the methanol leaf extract of Clerodendrum volubile, (MCV) family - Labiatae on experimental animals at 200-800 mg/kg body weight respectively. The animals were observed for different indicators of diuresis such as volume, electrolyte concentration, and pH of urine for 5 hours using standard methods. Methanol leaf extract of Clerodendrum volubile (MCV) induced diuresis and produced a non-significant increase (p<0.05) in urine output when compared to the negative control group. The 200 mg/kg dose of MCV produced the highest volume. In addition, the extract produced non-significant increase in the saliuretic and natriuretic activity when compared with furosemide 10 mg/kg. MCV may still be considered to have favorable natriuretic effects since the computed values were above 2.0 which is the benchmark for natriuretic effects. From this study, it can be inferred that MCV may have diuretic activity thus justifying its ethnomedicinal use in the management of fluid over load.enClerodendrum volubile; Leaf; Diuretic; Saliuretic; RatsArticle