Ayinde, T.O.,Ojulari, L.S.,Afodun, A.M.,Oluwasola A.,Balogun M.E.,Olanrewaju M.O.Tajudeen O.A.,Faramade A.A.2024-04-232024-04-232021Annona muricata, renal failure, nephro-protection, adenine.2354 1784https://uilspace.unilorin.edu.ng/handle/123456789/12678Renal failure is a prevalent disease in Africa, partly as a result of indiscriminate consumption of various medical herb preparations such as Annona muricata, which is locally used for several ailments like inflammation, bacterial and parasitic infections, diabetes, liver diseases amongst others. The present study was aimed at investigating the effect of Annona muricata leaf (AML) extract on adenine-induced renal failure in male Wistar rats. Thirty-five rats were divided into five groups, with seven rats per group. Each of the rats in groups II-V were given 50mg/kg adenine for induction of renal failure for a period of 14 days. The rats in groups III V were treated with 50mg/kg, 100mg/kg and 200mg/kg of the extract respectively following induction of renal failure, while group II was left untreated for a period of 28 days totaling 42 days all together. Rats in group I served as Control. Urinalysis was done prior to the end of the experiment. The animals were euthanised and blood samples collected for assessment of haematocrit, plasma electrolytes, urea and creatinine. Significant sodium reduction was observed in co-administration of 50mg AML and 50mg adenine, and 50mg adenine alone. Significantly increased potassium was noticed in co-administration 50mg AML and 50mg adenine, and 50mg adenine alone. Significant increase was noted in both urea and creatinine levels of co-administration of 50mg or 100mg AML and 50mg adenine. Haematocrit was only significantly increased in the 200mg AML administration group. There was global proteinuria in all AML intervention groups which was seemingly dose dependent.AML, if administered at a high dose has a nephron-protective effect against acute renal failure perhaps due to modulation in some ion channels in renal tubules.enArticle