Ayinla M.TOwoyele, B.V.Yakubu, M.T.Bilamin, S.2025-05-022025-05-022018Ayinla, M.T., Owoyele, B.V., Yakubu, M.T. & Bilamin, S. (2018). Amelioration of haematological alterations in streptozotocin-induced diabetic rats by aqueous leaf extract of Senna fistula. LASU Journal of Medical Sciences. 3 (1); 18-23, Published by Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja. Available on line at https://lasujms.org/view_volume.php?volume=3&issue=1&year=20182672-51932736-1357https://uilspace.unilorin.edu.ng/handle/123456789/15881Objectives: This study investigated the effects of aqueous leaf extract of Senna fistula on some haematological parameters, glucose-6-phosphate dehydrogenase activity, lipid peroxidation and osmotic fragility changes in streptozotocin-induced diabetic rats. Methods: Thirty albino rats were divided into six groups (A-F). such that A was the control non-diabetic, B was the diabetic that received distilled water, C was the diabetic group treated with 2.5 mg/kg body weight of glibenclamide while animals in groups D-F were made diabetic and treated with different doses (28.57, 57.14 and 114.28 mg/kg body weight) of the extract for 28 days. Results: Packed cell volume (PCV), red blood cell count (RBC), haemoglobin (Hb) and platelets count were decreased in diabetic untreated rats, but administration of the extract significantly increased (p<0.05) these values. Treatment with aqueous leaf extract of Senna fistula also increased the resistance of erythrocytes to lysis as evidenced by the median mean corpuscular fragility (MCF50) of 0.72% in diabetic rats and 0.58%, 0.57% and 0.58% after administration of the extract. Similarly, treatment with aqueous leaf extract of Senna fistula decreased the elevated Malondialdehyde level (p<0.05) of diabetic rats. Glucose-6-phosphate dehydrogenase activity increased significantly in the extract-treated groups and these compared favourably with the control non-diabetic and glibenclamide-treated groups. Conclusion: This study concludes that the extract might improve the diabetic-induced disturbances of some haematological parameters by reducing lipid peroxide level and susceptibility of red blood cells to haemolysis.enMalondialdehydeglibenclamidehaemoglobinstreptozotocinosmotic fragilityhaemolysis