Arise, R.O.Arise, A.k.Malomo, S.OOyewole, I.O.2018-06-082018-06-082013http://hdl.handle.net/123456789/433Monosodium glutamate (MSG), an established excitotoxic food additive, has been found to induce oxidative stress in all tissues. To examine the protective effects of ivermectin on MSG-induced excitotoxicity, twenty-eight male albino rats were randomized into group 1, the control, which received 1 ml oral administration of distilled water; group 2, aqueous solution of MSG (4 mg/kg body weight/day); group 3, co-administered with the same dose of MSG and 0.4 mg/kg body weight of ivermectin; group 4,orally administered with the same dose of MSG for 2 weeks after which ivermectin was orally administered for 1 week. Oral administration of MSG for 21 days, and for only 14 days followed by oral administration of ivermectin for 7 days, significantly increased (p<0.05) glutathione-Stransferase, nitric oxide synthase, superoxide dismutase and catalase activities as well as malondialdehyde and intracellular Ca2+ concentrations while the activities of Na+-K+- ATPase, Ca2+- Mg2+-ATPase, acid phosphatase and alkaline phosphatase were significantly reduced (p< 0.05) when compared with the control. However, co administration of MSG and ivermectin for 21 days showed no significant difference (p>0.05) in all the parameters investigated when compared with the control. This result suggests that ivermectin may exert protection against MSG-induced excitotoxicity in rats.enMonosodium glutamate,ivermectin,excitotoxicity,oxidative stressArticle