Sulaiman, F.A., Iyiola, O.A., Sulaiman, A.A., Quadri, A.L., Oyegoke R.A., Adisa, M.J., Adeyemi, S.B., Adebayo, M.A. & Itadare, O.B.2024-05-102024-05-102017-01https://uilspace.unilorin.edu.ng/handle/123456789/14039Silver nanoparticles (AgNPs) have numerous biomedical uses due to its excellent biocompatibility, antibacterial activity, antiviral, antifungal and anti inflammatory activity. The present research was carried out with the aim to determine effect of silver nanoparticles (AgNps) and colchicine on albino wistar rats. The silver nanoparticle was administered at the dosages of 1.11, 1.48, 1.85 and 2.22 mg/kg rat body weight to groups B to E respectively. Group A, which serve as the positive control group was administered with distilled water while group F was treated with a reference drug, called colchicine. The rats were sacrificed under slight anaesthesia twenty-four (24) hours after the last treatment and the effect of the silver nanoparticles and the colchicine on different enzymes and substrates in serum and selected organs were studied. Administration of silver nanoparticle has no significant differences (p > 0.05) on the average body weight, weight of organs and organ-body weight ratios of test rats when compared with the positive control rats. Administration of the silver nanoparticles to the test groups causes a significant alteration (p < 0.05) on the activities of alanine transferase, aspartate transferase, alkaline phosphatase and concentrations of total protein, albumin, urea and creatinine compared with the positive control group. The results obtained suggested that the effects of silver nanoparticles on hepatocytes at high doses (1.85mg/kg and 2.22mg/kg) led to the disruption and leakage of its enzymes into the blood stream. High concentrations of alkaline phosphatase (ALP), Alanine transaminase (ALT) and Aspartate transaminase (AST) were found the serum of the rats, indicating liver damage. We therefore recommend that the usage of silver nanoparticles as drug carrier should be at low doses to prevent hepatotoxicity and other related health issues.enSilver nanoparticlesColchicineLiver function markersKidney function markerstoxicityArticle