Attah, F. AChukwudulue, U. M.Diyaolu, O. A.Njinga, N. S.Abdullahi, A. A.Agunu, A.Musa, K. Y.2021-12-102021-12-102020-03ISSN: 0189-823Xhttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7138Painful and inflammatory diseases such as arthritis, backache, headaches, asthma and peptic ulcer disease are widespread and highly prevalent. The existing drugs for these conditions are liable to sub-optimal efficacy, intolerable adverse effects, prohibitive costs or limited availability. This scenario calls for renewed search for additional anti-inflammatory and analgesic agents. Hence, in line with the Traditional uses of plants, this study investigated the ethanol extract of Saba comorensis (Bojer ex. A.DC.) Pichon, for its safety, anti-inflammatory and analgesic effects in rodents using standard experimental protocols. The LD50 (i.p.) for the ethanol extract obtained from the geometric mean of doses was 770 mg/kg. Compared with the negative controls, the ethanol extract exhibited significant (p<0.05) and dose-dependent anti-inflammatory, ulcerogenic and dose-independent analgesic effects, while the petroleum extract did not induce any significant ulcerogenic effects. These findings suggest Saba comorensis ethanol root extract may be relatively safe and possesses anti-inflammatory and analgesic properties and may justify its use as traditional remedy for painful and inflammatory conditions. There is the need to investigate the study plant further for anti-inflammatory and analgesic drug discoveryenEthnomedicineinflammationgastric ulcersnociceptionRodentsArticle